Exercise Training Clinical Trial
Official title:
The Effect of Ischemic Preconditioning and Physical Exercise on the Endocrine Function of Skeletal Muscle - the Effect of CoQ10 Supplementation. In Vivo and in Vitro Studies.
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles. In the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | September 30, 2026 |
Est. primary completion date | July 31, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 21 Years to 29 Years |
Eligibility | Inclusion Criteria: - gender (males only), - not taking medication during the study, - good health (no concomitant injuries), - negative history of cardiovascular disorders, autonomic nervous system, mental disorders, cerebrospinal injuries and other diseases that may directly affect the results obtained. Exclusion Criteria: Lack of consent to participate in the research project or negative result of medical examinations. |
Country | Name | City | State |
---|---|---|---|
Poland | Jedrzej Antosiewicz | Gdansk | Pomorskie |
Lead Sponsor | Collaborator |
---|---|
Medical University of Gdansk |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The effects of IPC on physical performance | IPC training will be combined with endurance exercise and VO2max and serum Lactate will be measured | 8 weeks | |
Primary | The effects of CoQ10 supplementation on physical performance | CoQ10 supplementation combined with endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response will be measured | 8 weeks | |
Primary | The effects of CoQ10 supplementation and IPC on physical performance | CoQ10 supplementation combined with IPC and endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response, ulic acid will be measured | 8 weeks |
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