Impact of Augmenting Exercise Intensity vs. Frequency

Exercise Training Clinical Trial

Official title:

Impact of Augmenting Exercise Intensity vs. Frequency on Peak Work Rate

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04295590
• Other study ID #: UCD Study
• Status: Active, not recruiting
• Phase: N/A
• Start date: September 30, 2019
• Est. completion date: April 10, 2020

Study information

• Verified date: March 2020
• Source: Queen's University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 16
• Est. completion date: April 10, 2020
• Est. primary completion date: April 10, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Recreational active (<3 hours per week of aerobic exercise)

• Willing to provide skeletal muscle biopsies

Exclusion Criteria:

• Cardiovascular or metabolic disease

• Athletes or individuals exceeding 3 hours per week of aerobic exercise

• Smokers

Related Conditions & MeSH terms

• Exercise Training

Intervention

Behavioral:
• Frequency comparison
One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).
• Intensity comparison
One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

Locations

Country	Name	City	State
Canada	Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University	Kingston	Ontario

Sponsors (2)

Lead Sponsor	Collaborator
Brendon Gurd, PhD	Queen's University

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Peak work rate	Change in Highest work rate achieved (30s period) during incremental exercise tests	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Secondary	Peak oxygen uptake	Change in Highest oxygen uptake achieved (30s period) during incremental exercise tests	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)
Secondary	Maximal citrate synthase activity	Change in maximal citrate synthase activity	Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)