Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women — FiRST  

Coronary Disease Clinical Trial

Official title: Prospective Evaluation of Coronary Artery Disease in Women Presenting With Cardiac Ischemia: an Anatomic and Physiologic Study Comparing Fractional Flow Reserve (FFR) and Instantaneous Free-wave Ratio (iFR) on Cardiac Catheterization With Findings of Inducible Ischemia on Non-invasive Stress Imaging

Status Enrolling by invitation

Clinical Trial Summary

A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).

Clinical Trial Description

The WOMEN FiRST (FFR iFR Revascularization Strategies Trial) study collects information from enrolled subjects to create a data repository. The data will be used to further elucidate recommendations for PCI of angiographically intermediate lesions (30-90% stenosis) in epicardial lesions in women by comparing FFR and iFR findings to findings of inducible ischemia on existing non-invasive stress imaging studies. Gender comparisons will also be made from archived and published research data sets from studies comprised up to 80% men. Data will also be stored long term for use in future undefined analyses. ;

Related Conditions & MeSH terms

• Cardiac Catheterization
• Coronary Disease
• Exercise Test
• Myocardial Perfusion Imaging
• Percutaneous Coronary Intervention

• NCT number: NCT04599192
• Study type: Observational [Patient Registry]
• Source: Yale University
• Status: Enrolling by invitation
• Start date: April 19, 2019
• Completion date: April 19, 2025