Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance

Exercise-induced Inflammation Clinical Trial

— FAT  

Official title:

Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance, Inflammation, Gene Expression and Epigenetic Signatures

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03259412
• Other study ID #: LoughboroughU
• Status: Completed
• Phase: N/A
• First received: August 4, 2017
• Last updated: March 26, 2018
• Start date: January 1, 2016
• Est. completion date: December 20, 2017

Study information

• Verified date: March 2018
• Source: Loughborough University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance exercise training study. The investigators aim to establish the potential mechanisms that might mediate performance changes at a cellular level.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: December 20, 2017
• Est. primary completion date: December 20, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• Males

• Healthy

Exclusion Criteria:

• Resistance exercise training within the past 6 months

• Vitamin or fish oil supplementation over the past 6 months

• Habitual use of anti-inflammatory drugs

• History of heart disease

• History of coagulation/bleeding disorder

• History of metabolic disease

• Serious allergy

• Known to have blood-borne virus

• Females (Due to differences in cell membrane incorporation of Omega-3 between the sexes and the testing schedule being unable to fit in with menstrual cycle, altering the blood markers that are being measured)

• Currently no symptoms of general illness

Related Conditions & MeSH terms

• Exercise-induced Inflammation
• Inflammation

Intervention

Dietary Supplement:
• Fish Oil
Fish Oil Capsule
• Placebo
Olive Oil capsule manufactured to mimic fish oil capsule

Locations

Country	Name	City	State
United Kingdom	Loughborough University	Leicester

Sponsors (1)

Lead Sponsor	Collaborator
Loughborough University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Strength	Quadriceps and Hamstring strength using an isokinetic dynamometer	Change from baseline strength at 11 weeks
Primary	Leg power	Dynamic leg power assessed through jump height on force platform	Change from baseline strength at 11 weeks