Effect of 4 Weeks Fish Oil Supplementation on Cycling Performance in Healthy Male Cyclists

Exercise-induced Inflammation Clinical Trial

Official title:

Effect of 4 Weeks Fish Oil Supplementation on Cycling Performance or Oxidative and Inflammatory Parameters in Healthy Male Cyclists

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03205241
• Other study ID #: R14-P72
• Status: Completed
• Phase: N/A
• First received: June 28, 2017
• Last updated: June 29, 2017
• Start date: April 2014
• Est. completion date: December 2014

Study information

• Verified date: June 2017
• Source: Loughborough University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Research Plan

Eleven trained cyclists have completed 4 cycling performance trials, before and after 4 weeks of fish oil supplementation and before and after 4 weeks of placebo with a 4 week washout between supplementation periods. During the performance trials blood, expired air and heart rate were collected. The blood samples have been used to investigate the production of inflammation resulting from the cycling performance test. Inflammation has been assessed using enzyme-linked immunosorbent assay for IL-6, which is an inflammatory cytokine. Work done from the cycling performance will be analysed to investigate whether there is a relationship with power and inflammation and whether this is modulated by fish oil supplementation.

Specific Aims

1. Does 4 weeks of Fish Oil supplementation attenuate the inflammatory response following high intensity cycling.

2. Is a modulation of the inflammatory response connected to cycling performance.

Hypotheses

1. Four weeks of n3-PUFA supplementation will reduce the inflammatory response

2. A reduction in inflammation will improve cycling performance

Anticipated Outcomes

A high level of cycling performance, indicated by a high average power, will be associated with high levels of systemic inflammation. n3-PUFA supplementation will decrease the level of inflammation and consequently cycling performance will be improved.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: December 2014
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• recreationally trained male cyclists

Exclusion Criteria:

• History of coagulation/bleeding disorder

• History of metabolic disease

• Serious allergy

• History of heart disease

• Regular use of anti-inflammatory drugs

• Vitamin or fish oil supplementation over the past 6 months

• Known to have blood-borne virus

• Females

Related Conditions & MeSH terms

• Exercise-induced Inflammation
• Inflammation

Intervention

Dietary Supplement:
• n-3 PUFA
n-3 PUFA capsules containing EPA and DHA
• Placebo
Olive oil capsules

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Loughborough University	University of Worcester

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Work Done	Work done measured in Joules from the Lode cycle ergometer during 15 minute cycling time trial	15 minutes during time trial