Study of Airway Inflammation in Relation to Exercise in Elite Athletes

Status Completed

Clinical Trial Summary

High school elite training programs are today more and more under development in several 'elite sport schools' in Belgium, in order to select and train future elite athletes already at young age. Little is known about the effects of sustained training on the potential development of asthma in adolescents during lung growth. It would be of great importance to be able to select the individuals at risk to develop exercise-induced asthma, already at the start of their enrollment in the 'elite sport school. This would allow physicians to follow their lung function parameters very closely and regularly; and, if necessary, start treatment early after the first signs of exercise-induced asthma.

Clinical Trial Description

Competitive swimmers, competitive indoor athletes and control individuals performing sports at a recreational level will be recruited for the study.

They will perform a sport-specific training (swimmers and controls: swimming for 90 minutes, indoor athletes: basketball or volleyball for 90 minutes)

Baseline measurements:

- Airway inflammation upper and lower airways will be assessed by collection of nasal fluid (nasal sponge will be inserted in nostril for 5 minutes), Fraction of exhaled Nitric Oxide measurement and sputum induction.

- Upper and lower airway symptoms will be assessed by questionnaires (SinoNasal Outcome Measure-22, Visual Analogue Score, Asthma Symptom Score and Juniper Score)

- Allergy will be assessed by skin prick test (on skin) and immunocap test (in blood, 1 tube of 10 ml).

- Lung function and nasal patency will be measured by spirometry and Peak Nasal Inspiratory Flow measurement.

- Exercise induced bronchoconstriction will be assessed by eucapnic voluntary hyperventilation test.

Measurements immediately after training:

- Collection of nasal fluid

- Assessment of upper airway symptoms (Visual Analogue Score)

- Spirometry and Fraction of Exhaled Nitric Oxide measurement

- Peak Nasal Inspiratory Flow measurement

Measurements 24 hours after training:

- Collection of nasal fluid

- Assessment of upper airway symptoms (Visual Analogue Score)

- Spirometry and Fraction of Exhaled Nitric Oxide measurement

- Peak Nasal Inspiratory Flow measurement

- Sputum induction

- Venous puncture (1 tube of 10 ml) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01942096
Study type	Observational
Source	Universitaire Ziekenhuizen Leuven
Contact
Status	Completed
Phase
Start date	December 2011
Completion date	August 2013

View Details

See also
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.