Effects of Supplementation With Ginseng and BCAA Improved Central Fatigue and Enhanced Attention During Exercise

Exercise Addiction Clinical Trial

Official title:

The Anti-fatigue Effect of Gojinsen® Drink

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05129917
• Other study ID #: TSMH No.13-023-A2
• Status: Completed
• Phase: N/A
• Start date: June 1, 2013
• Est. completion date: December 31, 2013

Study information

• Verified date: November 2021
• Source: TCI Co., Ltd.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main purpose of the present study is to determine the effects of acute and short-term (14 days) ginseng combined with branch chained amino acids supplementation on endurance exercise performance and the ability of anti-fatigue. In addition, this study also measured the performance of continuous attention during recovery period to examine the effect of supplementation on central fatigue.

Description:

Muscle fatigue was a common problem after exercise. When fatigue occured, body functions were affected and changed. Changbai Mountain ginseng had higher anti-fatigue substances than general commercial ginseng. And recent studies had showed that the supplementation of branched chain amino acids (BCAA), including leucine, isoleucine and valine, can increase attention and reduce fatigue. However, its effect on Changbai Mountain ginseng combined with BCAA was still unclear. Subjects were allocated to Gojinsen® drinks and placebo group (1:1 ratio) for 14 days, and then examined by maximal oxygen consumption, time to exhaustion, rating of perceived exertion (RPE), oxygen saturation (SPO2) , blood lactate concentration, and continuous attention performance test (CPT II). The Gojinsen® group significant increased maximal oxygen consumption, time to exhaustion, and attention compared to placebo group. Moreover, the Gojinsen® group significant decreased lactate concentration and fatigue compared to placebo group. By this study, Gojinsen® drinks did not showed absolute anti-fatigue effect but provided the objective evidence of fatigue-related measurement and the therapeutic potential for people suffering from exercise fatigue.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: December 31, 2013
• Est. primary completion date: December 1, 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 25 Years

Eligibility

Inclusion Criteria:

1. healthy male and female adults aged 20-25 years old .

2. without heart, liver, kidney, endocrine or other major organic diseases).

3. had at least 3 months experience in performing exercise

Exclusion Criteria:

1. BMI of the study subjects must be less than 25.

Related Conditions & MeSH terms

• Exercise Addiction
• Fatigue

Intervention

Dietary Supplement:
• Placebo
consume 1 sachet per day for 14 day
• Gojinsen® drinks
consume 1 sachet per day for 14 day

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
TCI Co., Ltd.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endurance exercise performance testing	the subjects arrived to the laboratory and wore the oxygen uptake mask of energy metabolism analyzer (Sensor Medics, Vmax29, USA) to measure the subjects' oxygen uptake	Execution on the 14th day
Primary	rating of perceived exertion	The Rated Perceived Exertion was measured during the treadmill exercise by Bruce Protocol, a gradual increase in the speed and the slope of the treadmill every 3 minutes.	Execution on the 14th day
Primary	blood lactate	fingertip capillary blood was placed in automated blood lactate analyzer	Execution on the 14th day
Primary	Continuous attention performance test	10 minutes after maximal exercise test, the subjects performed attention tests that used Canon continuous attention software	Execution on the 14th day