A Clinical Trial of PRAX-944 in Participants With Essential Tremor

Status Completed

Clinical Trial Summary

This is a 2-part clinical trial to evaluate the efficacy, safety, and tolerability of 40 and 120 mg oral PRAX-944 compared to placebo in the treatment of adults with essential tremor. Part A is designed to study the dose titration from 20 to 40 mg every morning (QAM) (ie, 2 weeks with 7 days at each dose level). Part B is designed to study the dose titration from 20 to up to 120 mg QAM with at least 14 days of dosing at the highest tolerated dose for each participant. Blood levels of PRAX-944 will also be measured throughout the trial and pharmacokinetics will be evaluated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05021978
Study type	Interventional
Source	Praxis Precision Medicines
Contact
Status	Completed
Phase	Phase 2
Start date	March 3, 2020
Completion date	March 24, 2022

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT05381688` - VIM DBS Respiratory Modulation: N-of-1 Trial
Recruiting	`NCT05101161` - Neurofeedback Using Implanted Deep Brain Stimulation Electrodes	N/A
Completed	`NCT02277106` - Evaluate SAGE-547 in Participants With Essential Tremor	Phase 2
Recruiting	`NCT05769933` - Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
Terminated	`NCT02678429` - Atlas Predicted DBS Settings in Essential Tremor	N/A
Terminated	`NCT02894567` - Evaluation of Directional Recording and Stimulation Using spiderSTN	N/A
Completed	`NCT02523807` - Tremor Monitoring Device	N/A
Active, not recruiting	`NCT02255929` - Gamma Knife Radiosurgery for Treatment of Essential Tremor	N/A
Completed	`NCT01223144` - Decision-making and Emotion Recognition in Essential Tremor	N/A
Completed	`NCT00906412` - Ventrointermediate Nucleus (VIM DBS) and Working Memory	N/A
Recruiting	`NCT05214222` - Penpulimab Plus Chemotherapy With/Without Anlotinib for Patients With Advanced Esophageal Squamous Cell Carcinoma	Phase 2
Completed	`NCT03051178` - Wearable Sensor for Responsive DBS for ET	N/A
Recruiting	`NCT03795935` - Relief From Side Effects: Clinical Use of Electrodes With Direction	N/A
Not yet recruiting	`NCT06036368` - Study to Evaluate Safety and Efficacy of Peroneal Transcutaneous NeuroModulation in Subjects With Parkinson's Disease and Essential Tremor	N/A
Recruiting	`NCT05968976` - Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET	N/A
Completed	`NCT06314139` - Tolerability and Efficacy of Continuous Theta-burst Stimulation for Essential Tremor: A Randomized Study.	N/A
Recruiting	`NCT04501133` - Sensory-specific Peripheral Stimulation for Tremor Management	N/A
Active, not recruiting	`NCT03560622` - Functional Neuroimaging Feedback for Focused Ultrasound Thalamotomy	N/A
Completed	`NCT00368199` - Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes	N/A
Completed	`NCT05106816` - The Effects of Vibrotactile Stimulation in Patients With Movement Disorders	N/A