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Clinical Trial Summary

Penpulimab plus chemotherapy with or without Anlotinib as first-line therapy for patients with advanced esophageal squamous cell carcinoma (Answer): A randomized two-arm clinical study.


Clinical Trial Description

This is a open-label, phase II study of Penpulimab plus chemotherapy with or without Anlotinib as first-line therapy in subjects With resectable advanced esophageal squamous cell carcinoma. The patients will be divided into two groups. In group A, Penpulimab plus chemotherapy with Anlotinib will be given every 3 weeks for 4-6 cycles in initial stage, then in maintenance treatment, Anlotinib and Penpulimab will be used every 3 weeks until disease progression or intolerance; In group B, Penpulimab plus chemotherapy will be given every 3 weeks for 4-6 cycles in initial stage, then in maintenance treatment, Penpulimab will be used every 3 weeks until disease progression or intolerance; ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05214222
Study type Interventional
Source Nanfang Hospital of Southern Medical University
Contact wei wang
Phone 020-61642136
Email [email protected]
Status Not yet recruiting
Phase Phase 2
Start date March 1, 2022
Completion date July 1, 2024

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