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Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect — ATAX  

Essential Tremor Clinical Trial

Official title:
Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect (ATAX)

Clinical Trial Summary

The proposed study aims to characterize ataxia occurring in essential tremor and essential tremor with DBS.

Clinical Trial Description

Objectives: In recent years, there has been a growing amount of evidence tying Essential Tremor (ET) to cerebellar dysfunction. This has been clinically observed, demonstrated through specific gait measures of ataxia (often involving tandem gait), and confirmed through Positron emission tomography (PET) imaging. Deep Brain stimulation for ET has become a widely utilized therapeutic intervention for patients, and the bilateral thalamic ventralis intermedius (VIM) is most commonly implanted. However, it has been noted that in some patients gait ataxia significantly worsens post-op. This initially was thought to be a result of disease progression, but recent studies have in fact shown that this is a DBS related phenomenon.

Methods: Participants will have two visits to either the Portland VA or Oregon Health & Science University (OHSU). At each visit, several assessments of balance, tremor, gait and balance, and DBS settings will be made. The gait and balance assessments will be performed by a unblinded and a blinded rater. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03769961
Study type Observational
Source Oregon Health and Science University
Contact
Status Terminated
Phase
Start date December 1, 2018
Completion date September 14, 2020
View Details
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