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Essential Tremor clinical trials

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NCT ID: NCT03952117 Recruiting - Essential Tremor Clinical Trials

Transcranial Direct Current Stimulation of the Motor Cortex in Essential Tremor

Start date: July 19, 2019
Phase: N/A
Study type: Interventional

The current research is aimed at using Transcranial Direct Current Stimulation (tDCS) as complementary therapeutic tool in the treatment of essential tremor. Patients will be randomized into two groups (tDCS-cathode vs. tDCS-sham) according to detailed protocol. Main outcome will be measured by the change in tremor amplitude using an accelerometer pre and post cathodal tDCS of the motor cortex. A total of 40 patients ought to be enrolled as specified in methodology. Secondary outcomes will assess TRG essential tremor rating assessment scale (TETRAS) as well as clinical monitoring.

NCT ID: NCT03935581 Active, not recruiting - Clinical trials for Neurologic Manifestations

Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor

ET004
Start date: April 25, 2019
Phase: N/A
Study type: Interventional

The objective of this study is to evaluate the safety and feasibility of Auto Focusing (AF) echo imaging using the ExAblate Neuro system

NCT ID: NCT03884231 Completed - Parkinson Disease Clinical Trials

A Post-Market Study Evaluating the Safety of Infinity DBS System With MR Conditional Labeling

Start date: April 10, 2019
Phase:
Study type: Observational

This is a study of subjects with the St. Jude Medical Infinity deep brain stimulation (DBS) system who undergo an MRI imaging procedure. Enrollment may occur before DBS implant, or when an MRI scan is planned in a subject with an existing implant. There will be a follow-up visit one month after the MRI procedure to document any adverse events and verify device functionality.

NCT ID: NCT03875404 Completed - Essential Tremor Clinical Trials

Next-Generation Pre-Operative Targeting for Thalamic DBS in the Treatment of Tremor

Start date: March 20, 2019
Phase: N/A
Study type: Interventional

Researchers are investigating improved methods of targeting deep brain stimulators for treatment of essential tremor relying on brain connectivity measures derived from MRI.

NCT ID: NCT03832712 Recruiting - Essential Tremor Clinical Trials

The Swedish Essential Tremor (SWEET) Trial

SWEET
Start date: June 30, 2018
Phase: N/A
Study type: Interventional

To evaluate the effect of deep brain stimulation (DBS) vs best medical treatment in essential tremor (ET) in a randomized, single-blinded controlled trial.

NCT ID: NCT03811405 Recruiting - Parkinson Disease Clinical Trials

Physiology, Imaging and Modeling of Essential Tremor

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

This project aims to investigate novel ways to deliver brain stimulation to Essential Tremor (ET) patients by introducing software changes to their existing devices. The study team aims to investigate safety and efficacy of these new stimulation parameters in patients with ET.

NCT ID: NCT03805750 Completed - Essential Tremor Clinical Trials

Trial of Cannabis for Essential Tremor

Start date: January 22, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is a pilot trial to evaluate the safety and efficacy of a combined oral formulation of THC and CBD in patients with Essential Tremor.

NCT ID: NCT03795935 Recruiting - Essential Tremor Clinical Trials

Relief From Side Effects: Clinical Use of Electrodes With Direction

RESCUED
Start date: September 17, 2018
Phase: N/A
Study type: Interventional

Deep Brain Stimulation (DBS) uses electrical pulses sent through a lead (insulated wire) to help stop unwanted symptoms in a variety of brain diseases, including the tremor seen in patients with Essential Tremor (ET). The current standard lead allows this stimulation to spread out uniformly in all directions. As these diseases progress, however, the amount of electrical stimulation required to stop the symptom usually increases. This may become problematic because the increased electrical stimulation required for advanced symptoms may spread outside the desired targeted area, and effect other parts of the brain and causing unwanted side effects. A new type of DBS lead has been developed which can steer, or focus, the electrical stimulation in a given direction toward the desired target area and away from areas that would cause side effects. We would like to quantify the benefit seen in patients who have been switched from the traditional lead to this new directional lead.

NCT ID: NCT03794661 Completed - Parkinson's Disease Clinical Trials

Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool

EVIDENT
Start date: June 26, 2019
Phase: N/A
Study type: Interventional

The objective of this clinical investigation is to characterize the clinical performance of Abbott's Clinician Programmer Electrode Screening Mode tool (InformityTM tool) in programming InfinityTM deep brain stimulation (DBS) systems for patients with Parkinson's disease (PD) or essential tremor (ET).

NCT ID: NCT03780426 Completed - Essential Tremor Clinical Trials

tSMS in Essential Tremor

Start date: October 1, 2018
Phase: Phase 2
Study type: Interventional

This is randomized double-blind study to study the hypothesis that transcranial static magnetic field stimulation of the primary motor cortex improves tremor in patients with essential tremor. Half of the patients will receive tSMS of the left hemisphere and the other half of the right hemisphere.