Essential Hypertension Clinical Trial
Official title:
Efficacy and Safety of Allisartan Isoproxil/Amlodipine Tablets in Patients With Essential Hypertension Uncontrolled With Amlodipine or Allisartan Isoproxil: A Phase III, Multicenter, Randomized, Double-blind, Parallel-controlled, 52-week Clinical Study
The main objective of the study will be to assess the efficacy and safety of Allisartan Isoproxil/Amlodipine (240 mg /5 mg) in patients with mild to moderate essential hypertension uncontrolled after 4-week treatment with Amlodipine besylate（5 mg) or Allisartan Isoproxil (240 mg) .
Amlodipine belongs to the calcium channel blocker (CCB) class of drugs, which acts as antihypertensive agent mainly via blocking calcium channels on the vascular smooth muscle cells to dilate blood vessels. Allisartan Isoproxil belongs to the ARB class of drugs,which can effectively exert antihypertensive effect. The combination of dihydropyridine CCBs and ARBs exerts synergistic antihypertensive effects. ;
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