Renal Sympathetic Modification in Patients With Essential Hypertension

Status Recruiting

Clinical Trial Summary

The purpose of this study is to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with essential hypertension, and evaluate safety and efficacy of the intervention.

Clinical Trial Description

Hypertension is a common cardiovascular disease, and is also an important risk factor for heart-brain-renal diseases, with relatively low controlled rate. Traditional pharmacological therapies are used in clinical practice without breakthrough for long time. Previous studies confirmed that sympathetic nerves activity contributed to development and perpetuation of hypertension. Renal ablation for sympathetic modification is a new method which is proved to be effective in decreasing sympathetic nerves activity. We assume that modifying renal sympathetic activity by ablation is effective and safe in treatment of hypertension. This trial is going to recruit 200 patients (Ablation group VS Control group = 1:1) with a follow-up duration of 3 years. Patients in ablation group will receive additional necessary anti-hypertensive medications besides expectant intervention, and patients in control group will receive appropriate anti-hypertensive medications only. We aim to observe the incident of composite cardiovascular events after renal sympathetic modification using THERMOCOOL® catheter in patients with hypertension, and evaluate safety and efficacy of the intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01417221
Study type	Interventional
Source	The Second Affiliated Hospital of Chongqing Medical University
Contact	Yuehui Yin, MD
Phone	0086-13508335502
Email	yinyh63@163.com
Status	Recruiting
Phase	N/A
Start date	August 2011
Completion date	December 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT03708601` - Prognostic Risk of Patients With Essential Hypertension for Cardiovascular Events (PROSPECT)
Not yet recruiting	`NCT05503953` - Phase III Study to Evaluate the Efficacy and Safety of AGSAVI in Patients With Essential Hypertension Inadequately Controlled With AGLS	Phase 3
Recruiting	`NCT05526703` - Clinical Trial to Evaluate the Efficacy and Safety of D064 and D701 Combination Therapy	Phase 3
Completed	`NCT06395194` - Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension	Phase 3
Not yet recruiting	`NCT06418074` - Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity	N/A
Completed	`NCT02890173` - Study of CS-3150 in Patients With Essential Hypertension	Phase 3
Completed	`NCT02944734` - Comparison of Efficacy and Safety of Combination Therapy and Monotherapy of Candesartan and Amlodipine for Dose-Finding in Patients With Essential Hypertension	Phase 2
Withdrawn	`NCT02096939` - Microvascular Function in Primary Aldosteronism	N/A
Recruiting	`NCT01956786` - Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	Phase 2/Phase 3
Completed	`NCT02553512` - Helius in Hypertension-I: The UK Hypertension Registry	N/A
Completed	`NCT01198249` - Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension	Phase 1
Completed	`NCT01001572` - Efficacy and Safety of Valsartan/Amlodipine in Patients With Mild to Moderate Essential Hypertension	Phase 3
Recruiting	`NCT00380289` - Early Metabolic Changes With Thiazide or Beta Blocker Therapy for Essential Hypertension	N/A
Completed	`NCT00139698` - Olmesartan Alone or in Combination With Hydrochlorothiazide in Subjects With Mild to Moderate Essential Hypertension	Phase 3
Completed	`NCT00288184` - Uric Acid in Essential Hypertension in Children	Phase 2
Completed	`NCT01289886` - Fimasartan (BR-A-657) Single Oral Dose in Healthy Subjects	Phase 1
Not yet recruiting	`NCT06041529` - Study to Evaluate the Efficacy and Safety of TEL/AML/CTD in Elderly Patients With Essential Hypertension	Phase 4
Completed	`NCT04470830` - A Study for PMS of AZL-M/CLD FDC in the Treatment of Participants With Essential HTN in South Korea
Completed	`NCT00758524` - A Study to Evaluate Efficacy and Safety of LCI699 in Participants With Essential Hypertension	Phase 2
Recruiting	`NCT05109013` - Juvenile Essential Arterial Hypertension and Vascular Function