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End Stage Renal Disease clinical trials

View clinical trials related to End Stage Renal Disease.

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NCT ID: NCT06406140 Enrolling by invitation - Clinical trials for End-stage Renal Disease

Study the Effect of Niacin on Lipoprotein (a) Concentration and Hyperphosphatemia in Hemodialysis Patients

Start date: March 15, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

The goal of this clinical trial is to learn if Niacin has an effect on lipoprotein (a) concentration and hyperphosphatemia, which represent strong risk factors for cardiovascular diseases, in End-stage renal disease (ESRD) patients undergoing hemodialysis. It will also learn about the safety of Niacin. The main questions it aims to answer are: - Does Niacin lower lipoprotein (a) concentration? - Does Niacin treat hyperphosphatemia in End-stage renal disease (ESRD) patients undergoing hemodialysis? Researchers will compare Niacin to a control group (taking no drug) to see if drug Niacin works to treat hyperphosphatemia and lower lipoprotein (a) concentration. Participants will: - Take drug Niacin or no drug every day for 3 months - Visit the clinic once every 2 weeks for checkups and tests All Patients will be subjected to the following: 1. Informed consent. 2. Demographics and history taking: Using Patient Data sheet. 3. Laboratory evaluation including: Kidney function tests: blood urea,serum creatinine, albumin ,uric acid. Complete blood count (CBC). Lipid profile:Lipoprotein (a),total cholesterol,triglyceride,high density lipoprotein (HDL), low density lipoprotein (LDL). Phosphorous, calcium, sodium, parathyroid hormone (PTH), alkaline phosphatase (ALP). C-reactive protein (CRP).

NCT ID: NCT06389617 Not yet recruiting - Clinical trials for End Stage Renal Failure

Different Doses of Intravenous Administered Dexamethasone Effecting Brachial Plexus Supraclavicular Block

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

To compare the analgesic properties of ultrasound guided supraclavicular block using ropivacaine 0.5% in arteriovenous fistula creation when used in combination with intravenous administered dexamethasone at 4mg and 8 mg as an adjuvant

NCT ID: NCT06378931 Not yet recruiting - Clinical trials for Secondary Hyperparathyroidism

Quality of Life Change in Patients Undergoing Parathyroidectomy With End-stage Renal Failure

Start date: April 15, 2024
Phase:
Study type: Observational

The purpose of this study is to characterize the quality of life change in patients undergoing parathyroidectomy with secondary hyperparathyroidism due to end-stage renal failure.

NCT ID: NCT06373575 Enrolling by invitation - Clinical trials for End-stage Renal Disease

IVC and Lung Ultrasound B-lines Guided Decongestion in Critically Ill ESKD Patients With Heart Failure

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

The objectives of this trial are to determine whether, in critically ill ESKD patients randomization to fluid removal guided by lung and inferior vena cava ultrasound, compared to standard care, leads to Improved pulmonary congestion (primary outcome); and safety (secondary outcome) in the short-term.

NCT ID: NCT06367205 Recruiting - Clinical trials for End Stage Renal Disease

Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients. The primary objective of this study is to investigate the potential efficacy of norepinephrine infusion in conjunction with goal-directed fluid therapy (GDFT) in mitigating the occurrence of DGF among individuals undergoing kidney transplantations. The findings of this investigation have the potential to advance the field of perioperative care in kidney transplantations by providing insights into optimized management strategies.

NCT ID: NCT06366230 Not yet recruiting - ESRD Clinical Trials

Adding Urea to the Final Dialysis Fluid

Start date: July 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and/or fix the metabolic acidosis.

NCT ID: NCT06350552 Recruiting - Clinical trials for End Stage Renal Disease

Prevalence of Postural Abnormalities in Dialysis Patients

Start date: April 28, 2024
Phase:
Study type: Observational

The goal of this observational study is to investigate and compare the prevalence of forward head , hyper kyphosis and balance in hemodialysis and peritoneal dialysis patients. The main questions it mains to answer are: What is the prevalence of forward head posture in hemodialysis and peritoneal dialysis patients? What is the prevalence of hyper kyphosis in hemodialysis and peritoneal dialysis patients? Is there any relation between postural abnormalities and physical function in hemodialysis and peritoneal dialysis patients? Participants will answer 2 questionnaires and will do some functional tests.

NCT ID: NCT06341452 Not yet recruiting - Clinical trials for End Stage Renal Disease

Comparison of Individualized Sodium Management Versus Standard Treatment in Hemodialysis

SODIAH
Start date: June 2024
Phase: N/A
Study type: Interventional

The SODIAH study is designed with the aim to assess the impact of isonatremic dialysis on interdialytic weight gain, fluid status, intradialytic hemodynamic stability, and incidence of intradialytic morbid events in dialysis patients. The study will be comparing the Na management option on the 6008 HD dialysis machines with the same machine without the Na management option turned on. Relevant performance and clinical data will be collected as well as information on patients' quality of life and wellbeing.

NCT ID: NCT06329310 Not yet recruiting - Clinical trials for End Stage Renal Disease

Xeltis Hemodialysis Access Conduit: aXess-E Study

Start date: July 2024
Phase: N/A
Study type: Interventional

A prospective, single arm, non-randomized feasibility study to confirm the safety and performance of the Xeltis Hemodialysis Access conduit, aXess-E, in subjects older than 18 years with end-stage renal disease, who plan to undergo hemodialysis for at least the first 6 months after study access creation.

NCT ID: NCT06327750 Not yet recruiting - Clinical trials for End-stage Renal Disease

The Microcirculation, Dialysis Modality and Sequestered Salt

MIMOSA
Start date: June 2024
Phase: N/A
Study type: Interventional

The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in adult prevalent end-stage kidney disease (ESKD) patients treated with hemodialysis (HD) or hemodiafiltration (HDF). The main questions it aims to answer are: 1. What are the effects on the sequestered sodium content and microcirculation after 4 weeks of treatment with the following dialysis modes? - HDF with an expected zero diffusive sodium balance (Dialysate sodium concentration (DNa)= Plasma sodium concentration (PNa)) compared to - HDF with an expected diffusive sodium efflux (DNa < PNa, difference 3 mmol/L) compared to - HD with an expected zero diffusive sodium balance (DNa = PNa) compared to - HD with an expected diffusive sodium efflux (DNa < PNa, difference 3 mmol/L) compared to - Isolated ultrafiltration for 30 minutes followed by HD with an expected zero diffusive sodium balance (DNa = PNa) 2. Are the SSC and MC interrelated in this patient group? This study is a randomized cross-over trial. Participants will be subjected to the abovementioned dialysis treatment modes in random order.