Esophageal Squamous Cell Carcinoma Clinical Trial
Official title:
Phase II Study of Concurrent Chemoradiotherapy With Itraconazole in Treating Patients With Locally Advanced Esophageal Squamous Cancer
The objective of this study is to evaluate the efficacy and safety of concurrent chemoradiotherapy combined with Itraconazole in patients with locally adcvanced esophageal squamous cancer
Esophageal cancer is one of the most lethal malignancies. Esophageal squamous cell carcinoma
(ESCC) is the predominant type in China, accounting for over 90% of all esophageal cancer.
Concurrent chemoradiation therapy (CCRT) remains the standard therapy of locally advanced
ESCC. However, the outcome remains poor.
The aberrant activation of Hedgehog (HH) signaling is associated with a variety of human
malignancies. Previous studies found that the reactivation of HH pathway occurs in 60% of
esophageal cancer. Targeting the Hh pathway for cancer therapy was expected to work wonders
in Hh-dependent cancers. Itraconazole, an antifungal agent, has been shown to inhibit the Hh
and AKT signaling pathways.
The aim of our study is to evaluate the efficacy and safety of concurrent chemoradiotherapy
combined with Itraconazole in patients with locally adcvanced esophageal squamous cancer
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