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Esophageal Perforation clinical trials

View clinical trials related to Esophageal Perforation.

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NCT ID: NCT05781022 Completed - Clinical trials for Iatrogenic Esophageal Perforation

Endoscopic Management Of Iatrogenic Esophageal Perforation After Laparoscopic Upper Gastrointestinal Surgery

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

The investigators included all patients who were presented to General Surgery Department with Iatrogenic Esophageal Perforation after Laparoscopic Upper Gastrointestinal Surgery at Zagazig University hospital between (December 2020 to August 2023).The sample size was calculated by using open Epi program depending on the following data ; confidence interval 95% , power of the test 80% , ratio of unexposed/ exposed 1 , the success rate of surgical repair versus endoscopic repair was 98 % versus 75% respectively. Odd ratio 16 , and risk ratio 1.3 , so the calculated sample size equal 84 patients divided into two equal groups. Included patients were randomized at a 1:1 ratio to "Endoscopic Group, EG" or "Surgical Group , SG" via the drawing of sealed envelopes containing computer-generated random numbers prepared by a third party before the start of the intervention.(simple random sample). Patients will be divided into 2 groups in accordance type of preoperative Therapy : Group 1: "Endoscopic Group, EG" included 42 patients. Group 2: "Surgical Group , SG" included 42 patients.

NCT ID: NCT05758805 Recruiting - Atrial Fibrillation Clinical Trials

Esophageal Injury of a Tip CF Sensing Ablation Catheter for HP-SD of Paroxysmal and Persistent AF (ESO-SAFE-HP-RF)

ESO-SAFE-HP-RF
Start date: January 8, 2024
Phase: N/A
Study type: Interventional

This pilot, prospective, interventional, monocentric, independent, and no-profit clinical trial aims to investigate and evaluate the proportion, acute and chronic characteristics, and outcomes of esophageal thermal injury (ETI) in AF ablation using a high-power, short-duration (HP-SD) setting with contact force (CF) sensing tip ablation catheter in standard clinical practice. The main questions it aims to answer are: - Evaluate the acute proportion of the ETI assessed by the mini-invasive esophagoscopy pre and post-procedure. In addition, clinical evaluations at 3, 6, and 12 months from the procedure are foreseen. - Evaluate the contribution of the factors influencing RF procedure (contact force, impedance, RF power, RF time) on ETI development. - Describe the relationship between the esophageal temperature (continuous monitoring) and ETI development.

NCT ID: NCT05606822 Recruiting - Anastomotic Leak Clinical Trials

Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract

Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

The goal of this observational study is to learn about the best indications and techniques regarding endoscopic vacuum therapy (EVT) in patients with a transmural defect in the upper gastrointestinal (GI) tract (e.g. anastomotic leakage, Boerhaave syndrome, iatrogenic perforation, other). The main questions it aims to answer are: - What is the success rate of EVT for transmural defects in the upper GI tract? - What are the best indications for EVT in the upper GI tract? (e.g. etiology, patient characteristics, defect characteristics) - What are the best techniques for EVT in the upper GI tract? (e.g. EsoSponge, VACStent, vacuum pressure, intraluminal/intracavitary) Participants will be asked for informed consent to retrospectively and prospectively collect data on EVT.

NCT ID: NCT04571541 Recruiting - Clinical trials for Esophageal Perforation

Endoscopic Management of Esophageal Wall Defects

Start date: July 1, 2014
Phase:
Study type: Observational

The study aim at comparing outcomes from the implementation of various endoscopic closure techniques including stenting and suturing on the healing and resolution of esophageal wall defects.

NCT ID: NCT03962179 Active, not recruiting - Esophageal Cancer Clinical Trials

Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)

VACStent
Start date: September 22, 2019
Phase: N/A
Study type: Interventional

Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication. Evaluation of the suitability of the medical device for sealing leaks in the gastrointestinal tract

NCT ID: NCT02751333 Withdrawn - Esophageal Fistula Clinical Trials

Esophageal Stent Migration With Endoscopic Suture Fixation Compared to Standard Deployment

Start date: March 2016
Phase: Phase 2
Study type: Interventional

Esophageal stents are commonly used for benign esophageal pathology, especially strictures or esophageal mucosal defects such as leaks, fistulae, or perforations. The major limiting factor to stent placement is the high migration rate of the stent. Investigators are trying to prospectively evaluate the efficacy of endostitch in preventing stent migration in benign esophageal disease in comparison with standard, fully covered self-expanding metal stents (FCSEMS) placement without fixation.

NCT ID: NCT02662777 Recruiting - Clinical trials for Leakage After Gastrectomy

Eso-Sponge Registry

Start date: January 2015
Phase:
Study type: Observational [Patient Registry]

This international, prospective and multicenter registry was designed to collect clinical evidence for the endoscopic vacuum treatment using Eso-SPONGE® for anastomotic leakage after esophageal resection or iatrogenic or spontaneous esophageal perforation.

NCT ID: NCT01900691 Completed - Clinical trials for Esophageal Neoplasms

Removal of the Evolution® Esophageal Stent - Fully Covered

CLARITY
Start date: September 2013
Phase: N/A
Study type: Interventional

The CLARITY study is a clinical trial approved by US FDA to study the removal of the Evolution® Esophageal Stent-Fully Covered in malignant and benign indications.

NCT ID: NCT00422760 Completed - Clinical trials for Esophageal Perforation

A 75 Year Old With Dyspnea a Case Report.Observational Study

Start date: January 2007
Phase: N/A
Study type: Observational

Clinical Case report Of spontaneous esophageal perforation in a 75 year old man. He prsented with breathlessness and on investigation found to have esophageal perforation