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Esophageal Neoplasms clinical trials

View clinical trials related to Esophageal Neoplasms.

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NCT ID: NCT03777813 Recruiting - Esophagus Cancer Clinical Trials

Association of Radiochemotherapy and Immunotherapy for the Treatment of Unresectable Oesophageal caNcer

ARION
Start date: December 5, 2018
Phase: Phase 2
Study type: Interventional

This study aims to assess the efficacy of durvalumab in combination with radiochemotherapy (FOLFOX and IMRT) and then as maintenance therapy for treating patients with localised unresectable oesophageal cancer. This is a randomized, French national, multicentre, comparative phase II trial

NCT ID: NCT03732508 Recruiting - Clinical trials for Advanced Esophageal Squamous Cell Cancer

SHR-1316 in Combination With Chemotherapy in Patients With Esophageal Squamous Cell Cancer

Start date: November 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the progression-free survival (PFS) of Chemotherapy combined with SHR-1316 in patients with advanced esophageal squamous cell cancer.

NCT ID: NCT03731442 Recruiting - Esophageal Cancer Clinical Trials

Salvage Chemoradiation Therapy for Recurrence After Radical Surgery or Palliative Surgery in Esophageal Cancer Patients

Start date: November 1, 2018
Phase: Phase 3
Study type: Interventional

Currently, adjuvant therapy is not recommended for patients with esophageal squamous cell carcinoma who received radical surgery. However, the recurrence rate is as high as 23.8%-58%, and the median time-to-recurrence is about 10.5 months. In patients who had residual tumor after surgery, evidence lacks for chemoradiation. The aim of the study is to evaluate the efficacy and safety of chemoradiation therapy in patients with recurrences after radical surgery or palliative surgery.

NCT ID: NCT03727126 Recruiting - Esophageal Cancer Clinical Trials

Robotic Versus Thoracolaparoscopic Esophagectomy for Esophageal Cancer

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

Esophageal cancer is a debilitating condition. The treatment involved is complex requiring a combination of chemotherapy and surgery in most cases. Complete removal of the tumor and the adjacent lymph nodes is of utmost importance in improving the survival. Lymph node yield following surgery helps in proper staging of the disease and is an important prognosticating variable. It is hypothesized that the lymph node yield following robotic esophagectomy is higher than that following thoracolaparoscopic esophagectomy. The study aims to compare the short term oncological outcomes following robotic esophagectomy and thoracolaparoscopic esophagectomy for carcinoma esophagus.

NCT ID: NCT03712774 Recruiting - Quality of Life Clinical Trials

Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant or Definitive Chemoradiation in Patients With Esophageal Cancer

ESOCARE
Start date: October 12, 2018
Phase:
Study type: Observational

Prospective observational study to evaluate the Quality of life based on standardized EORTC questionaires as well as toxicities, functional and oncological outcomes in patients treated with neoadjuvant or definitive chemoradiation for esophageal Cancer.

NCT ID: NCT03706326 Recruiting - Clinical trials for Advanced Esophageal Cancer

CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer

Start date: September 28, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The study is to assess the safety and efficacy of the immunotherapies using anti-MUC1 CAR T cells and /or PD-1 knockout engineered T cells in the treatment of patients with advanced esophageal cancer.

NCT ID: NCT03700398 Recruiting - Clinical trials for Optical Enhancement Endoscopy

Early Detection of Head and Neck Superficial Squamous Cell Carcinoma in Patients With Esophagus Squamous Cell Carcinoma

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

the investigators randomly divide the eligible objects into two groups:1. objects in this group will first receive OE endoscopy observation and subsequent white light imaging(WLI) observation during oropharynx and hypopharynx; 2. objects in this group will first receive WLI observation and subsequent OE observation during oropharynx and hypopharynx. Then, the investigators will compare the detect rate of oropharyngeal and hypopharyngeal superficial squamous cell carcinoma of two groups to find if OE endoscopy can improve the detect rate of oropharyngeal and hypopharyngeal superficial squamous cell carcinoma in esophageal cancer patients.

NCT ID: NCT03676478 Recruiting - Esophageal Cancer Clinical Trials

Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival

EFECTS
Start date: March 25, 2019
Phase: N/A
Study type: Interventional

The surgical stress of an esophagectomy causes a detrimental impact on the physiological response of the body. In this perspective, one could question whether the current feeding regimens of starting early nutritional support at postoperative day (POD) 1 have a similar negative impact on the muscle mass as documented in critically ill patients. This study will introduce relative starvation in the early days following esophagectomy compared to the current regimen of early enteral nutritional support. The research team aims to investigate whether the negative impact on muscle mass and muscle function might be reduced, which should result in enhanced postoperative recovery. The final result of the study will be a well-documented and scientifically substantiated nutritional regimen for patients who underwent an esophagectomy for cancer.

NCT ID: NCT03671265 Recruiting - Esophageal Cancer Clinical Trials

Combination of Chemotherapy Plus RT and SHR-1210 to Treat Patients With ESCC

Start date: September 17, 2018
Phase: N/A
Study type: Interventional

SHR-1210 is a humanized anti-PD1 IgG4 monoclonal antibody. This is an openlabel,single center ,non-randomized ,Single Arm Exploratory Study . This clinical study is an investigator-initiated clinical trial(IIT). The objective of this study is to evaluate the efficacy and safety of radiation therapy combined with anti-PD-1 antibody SHR-1210 and chemotherapy in patients with Locally Advanced Esophageal Squamous Cell Carcinomas。

NCT ID: NCT03668418 Recruiting - Pancreatic Cancer Clinical Trials

Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos

xenoZ
Start date: June 1, 2018
Phase:
Study type: Observational

The study consists in a co-clinical trial by using zebrafish embryos. Specifically, an observational prospective clinical trial on patients operated of epato-biliar-pancreatic cancers and gastro-intestinal cancers undergoing a chemotherapy treatment will be run concurrently to an animal trial on zebrafish embryos xenotransplanted with patient cancer cells in order to demonstrate that zebrafish model is able to predict the therapeutic regimen with the best efficacy for each patient.