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NCT06424210 Clinical Trial

The Role of Surgery for Esophageal Cancer With Metastatic Disease (M1)

Esophageal Cancer Clinical Trial

Official title:
The Role of Surgery for Esophageal Cancer With Metastatic Disease (M1)

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06424210
Other study ID # 202211084RIND
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 15, 2023
Est. completion date June 1, 2023

Study information
Verified date February 2023
Source National Taiwan University Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Treatment of stage IV esophageal cancer is traditionally palliative, but treatment response is usually poor. The role of surgery in the treatment of advanced esophageal cancer remains controversial. We sought to determine whether surgical treatment followed by neoadjuvant chemoradiation therapy might provide survival benefits for these patients. A retrospective review of esophageal cancer patients with M1 disease treated at National Taiwan University Hospital was performed from April 2002 to June 2021. Patient demographics and cancer staging, treatment, and disease recurrence, and time of follow up were included for analysis. Univariate and multivariate analysis was performed for overall survival and progression-free survival analysis. Propensity score matching based on patient age and tumor staging characteristics was also performed for analysis.

Recruitment information / eligibility
Status Completed
Enrollment 163
Est. completion date June 1, 2023
Est. primary completion date June 1, 2023
Accepts healthy volunteers
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria: - Stage IV Esophageal Cancer patients - Patients were treated with chemoradiation therapy (CCRT) Exclusion Criteria: - Not Stage IV Esophageal Cancer patients - Patients were not treated with chemoradiation therapy (CCRT)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Taiwan National Taiwan University Hospital Taipei Zhongzheng

Sponsors (1)
Lead Sponsor Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Overall survival and progression-free survival Overall survival (OS) and progression-free survival (PFS) curves of patients with or without esophagectomy in the entire study cohort of stage IV esophageal cancer with distant metastasis. 5 years
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