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Clinical Trial Summary

To demonstrate that combination of cabozantinib and atezolizumab is safe and efficacious in patients with recurrent/metastatic esophageal squamous cell carcinoma.


Clinical Trial Description

Patients with histologically proven squamous cell carcinoma of esophagus and had progression from first-line platinum-based chemotherapy for recurrent or metastatic ESCC, or progression within 6 months after neoadjuvant, definitive, or adjuvant chemo(radio) -therapy for loco-regional ESCC would be eligible for this trial. Eligible patients will receive daily 40mg cabozantinib plus i.v. atezolizumab 1200mg Q3W for treatment response evaluation. Primary endpoint is the objective response rate, and secondary endpoints include progression-free survival, overall survival, and safety profiles. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05007613
Study type Interventional
Source National Taiwan University Hospital
Contact Hung-Yang Kuo, M.D.
Phone +886-2-23123456
Email hungyang.kuo@gmail.com
Status Recruiting
Phase Phase 2
Start date June 23, 2021
Completion date June 23, 2023

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