Esophageal Cancer Clinical Trial
Official title:
Phase I Study of Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy in Patients With Resectable Esophageal Cancer
The purpose of this study is to see whether giving azacitidine before each cycle of chemotherapy prior to surgery is safe.
Currently patients with resectable (can be removed by surgery) esophageal cancer will receive
chemotherapy before surgery to try to shrink the tumor before it is removed. This study will
evaluate whether giving azacitidine before each cycle of chemotherapy to increase the
shrinkage of the tumor prior to surgery is safe.
Azacitidine is currently approved by the Food and Drug Administration (FDA) for treatment of
myelodysplastic syndrome (MDS). Azacitidine is not approved by the FDA for use in this study
and is therefore considered investigational. Because azacitidine has not been given before in
combination with epirubicin, oxaliplatin and capecitabine, we will also evaluate the safety
and tolerability of azacitidine and find out what dose of azacitidine is safe to give with
this chemotherapy.
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