Epilepsy in Children Clinical Trial
Official title:
Biochemical Role of Nucleotide Protein -3 That Activate the Interleukin-1B in Epileptic Children
Epilepsy is one of common serious neurological malfunction, characterized by recurrent
unprovoked seizures. It always accompanied with multitude of complications as cognitive,
behavioral, and psychiatric disorders.
Experimental studies and clinical evidence obtained in animal models of epilepsy and human
brain specimen from various drug-resistant forms of epilepsy show the activation of the
innate and adaptive immunity mechanisms and the induction of the associated inflammatory
processes in the epileptogenic foci.
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | December 1, 2020 |
Est. primary completion date | November 1, 2020 |
Accepts healthy volunteers | |
Gender | All |
Age group | 2 Years to 17 Years |
Eligibility |
Inclusion Criteria: - Epileptic children in Assiut university hospital, pediatric department, neurology unit. Exclusion Criteria: - Children with other chronic disease such as liver, kidney or heart disease - patient who have apparent infection |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Farghaly WM, Abd Elhamed MA, Hassan EM, Soliman WT, Yhia MA, Hamdy NA. Prevalence of childhood and adolescence epilepsy in Upper Egypt (desert areas). Egypt J Neurol Psychiatr Neurosurg. 2018;54(1):34. doi: 10.1186/s41983-018-0032-0. Epub 2018 Nov 9. — View Citation
He Q, Jiang L, Man S, Wu L, Hu Y, Chen W. Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model. Curr Neurovasc Res. 2018;15(3):186-192. doi: 10.2174/1567202615666180731100224. — View Citation
Xu D, Miller SD, Koh S. Immune mechanisms in epileptogenesis. Front Cell Neurosci. 2013 Nov 8;7:195. doi: 10.3389/fncel.2013.00195. eCollection 2013. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The mean difference of nucleotide protein -3 inflammatory marker expression in epileptic children and controls | better understanding the role of inflammation in pathogenesis of epilepsy in children | Baseline |
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