Epilepsy in Children Clinical Trial
Official title:
Comparison of Microbiome Composition and Biomarkers in Pharmaco Resistant and Pharmaco-Sensitive Epilepsy
The purpose of this study is to determine stool microbiome composition and biomarkers that are differentially abundant and those that are associated with response to treatment (eg, anticonvulsant drugs).
Recent research suggests that the intestinal microbiota plays a central role in human health, and may play a role in a variety of central nervous system disorders, including seizure susceptibility. The microbiota has been shown to be associated with changes in factors relevant to neurotransmission, including neurotransmitter signaling, synaptic protein expression, long-term potentiation, and myelination. In addition to the microbiota's potential role in general neurotransmission, research suggests that the gut microbiome may differ between patients with pharmaco resistant and pharmaco-sensitive epilepsies. In support of this idea, ketogenic diet has been used as an alternative treatment for those with pharmaco-resistant epilepsy and there are indications of possible direct interactions of anti-epileptic drugs (AEDs) with the intestinal microbiota. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06202976 -
Mapping Epileptic Networks Using Multimodal Imaging
|
||
| Recruiting |
NCT04770337 -
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy
|
N/A | |
| Recruiting |
NCT05885646 -
Effect of Sulthiame on EEG in Childhood Epilepsy Syndromes
|
||
| Completed |
NCT04545346 -
The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
|
N/A | |
| Not yet recruiting |
NCT06388577 -
The Effect of the Training Programme Based on the Health Promotion Model Given to Parents
|
N/A | |
| Terminated |
NCT04639310 -
XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy
|
Phase 3 | |
| Recruiting |
NCT06300814 -
The Effect of Exercise and Music on Sleep, Quality of Life and Emotional State in Children With Epilepsy
|
N/A | |
| Active, not recruiting |
NCT03916848 -
Novel Network Analysis of Intracranial Stereoelectroencephalography
|
N/A | |
| Recruiting |
NCT05439876 -
Getting SMART for Pediatric Epilepsy
|
Phase 2/Phase 3 | |
| Recruiting |
NCT05323682 -
Physical Excercise Program in Children With Drug-resistant Epilepsy
|
N/A | |
| Recruiting |
NCT04584385 -
Advanced EEG Technology in Childhood Epilepsy
|
||
| Not yet recruiting |
NCT04219930 -
Nucleotide Protein -3 in Epileptic Children
|
||
| Completed |
NCT04020484 -
Making Mindfulness Matter© in Children With Epilepsy
|
N/A | |
| Recruiting |
NCT06093490 -
Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings
|
||
| Completed |
NCT05675254 -
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
|
||
| Recruiting |
NCT05740423 -
Standardization of Anti-Seizure Medications Withdrawals After Seizure Remission in Young Patients With Epilepsy
|
||
| Terminated |
NCT04912856 -
An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
|
Phase 3 | |
| Recruiting |
NCT06310954 -
Ketogenic Diet in Pediatric Intractable Epilepsy
|
N/A | |
| Completed |
NCT03800992 -
Bad News- Diagnosis: Epilepsy in Childhood
|
||
| Enrolling by invitation |
NCT06376279 -
Genetic Diagnosis in Inborn Errors of Metabolism
|