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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00266565
Other study ID # 01-9-18
Secondary ID FD-R-002396
Status Completed
Phase Phase 1/Phase 2
First received
Last updated
Start date December 2001
Est. completion date April 2005

Study information

Verified date July 2020
Source Children's Hospital Medical Center, Cincinnati
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Toxicity of anti-IL-5


Description:

The purpose of the study is to assess the toxicity of anti-IL-5, and to see whether it lowers peripheral blood eosinophils and/or tissue and whether it has a steroid and/or interferon sparing effect.


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Study Design


Intervention

Drug:
Mepolizumab
10mg/kg (max 750 ml) once a month for 3 months

Locations

Country Name City State
United States Cincinnati Children's Hospital Medical Center Cincinnati Ohio

Sponsors (1)

Lead Sponsor Collaborator
Children's Hospital Medical Center, Cincinnati

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary To assess the toxicity of anti-IL-5 in patients with hypereosinophilia 28 weeks
Secondary To assess whether anti-IL-5 lowers peripheral blood eosinophils and/or tissue in patients with hypereosinophilia 28 weeks
Secondary To assess whether anti-IL-5 has a steroid and/or interferon sparing effect 28 weeks
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