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NCT00426699 Clinical Trial

Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection

Enterovirus Infections Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00426699
Other study ID # BE002
Secondary ID
Status Completed
Phase N/A
First received January 24, 2007
Last updated May 18, 2011
Start date June 2006
Est. completion date November 2008

Study information
Verified date May 2011
Source University Hospital Inselspital, Berne
Contact n/a
Is FDA regulated No
Health authority Switzerland: Ethikkommission
Study type Observational

Clinical Trial Summary

Enteroviruses can infect most human organ systems, especially the heart, nervous system and pancreas. Whether Enteroviruses can also affect the kidneys is not known yet. Therefore we will analyze urine of children with a suspected enteroviral infection for enteroviruses and signs of kidney infection.

Description:

Enteroviruses have been shown to cause mesangioproliferation and glomerulonephritis in mice (especially coxsackievirus B4). In some cases, large amounts of IgA are deposited in the mesangium, resembling human IgA-nephropathy. In humans, case reports indicate the propensity of certain enteroviruses to cause kidney infections.

Our project aims to analyze urine of children with suspected enteroviral infections (e.g. meningitis, myocarditis, sepsis of the newborn etc.) to identify cases suspicious of concomitant enteroviral kidney affection. To achieve this aim, enterovirus-PCRs will be performed and microhematuria searched for.

Recruitment information / eligibility
Status Completed
Enrollment 82
Est. completion date November 2008
Est. primary completion date November 2008
Accepts healthy volunteers No
Gender Both
Age group N/A to 16 Years
Eligibility Inclusion Criteria:

- children, suspected of suffering from an enteroviral infection

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Switzerland Dept. Nephrology & Hypertension, Univ. Hospital Bern Bern

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Inselspital, Berne

Country where clinical trial is conducted

Switzerland, 

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