Enteric Oxalate Absorption Study in Unclassified Hyperoxaluria

Status Completed

Clinical Trial Summary

The purpose of this study is to learn more about a condition called 'unclassified hyperoxaluria'. People with this condition have large amounts of oxalate in their urine, which can cause kidney stones and kidney failure. We do not know what causes the high level of oxalate in the urine. In this study, we will evaluate absorption of a test dose of oxalate taken orally by measuring the amount of the test dose that is eliminated in the urine. We will compare the results of affected patients to healthy volunteers.

Clinical Trial Description

Participants' oxalate intake and output will be monitored and assessed over a 24 hour period. Participants will ingest a prescribed oxalate dose and urine oxalate will be monitored for the 24 hour study period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00588120
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Completed
Phase	Phase 1
Start date	December 1998
Completion date	January 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06138327` - A Study of BMN 255 in Participants With Non-Alcoholic Fatty Liver Disease And Hyperoxaluria	Phase 1
Completed	`NCT02547805` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days	Phase 2
Completed	`NCT02289755` - Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria	Phase 2
Completed	`NCT02038543` - Hydroxyproline Influence on Oxalate Metabolism	Phase 1/Phase 2
Completed	`NCT03095885` - A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria	N/A
Recruiting	`NCT02780297` - Prospective Research Rare Kidney Stones (ProRKS)
Completed	`NCT01127087` - Oxazyme in Patients With Hyperoxaluria	Phase 1/Phase 2
Not yet recruiting	`NCT05443932` - Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients	Phase 4
Completed	`NCT04756024` - Reference Interval of Spot Urinary Oxalate to Creatinine Ratio in Children
Completed	`NCT02503345` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones	Phase 2
Completed	`NCT00199459` - Proteomic Study of Urinary Stone Disease	N/A
Completed	`NCT04119765` - Plasma Oxalate in Patient With Short Bowel
Completed	`NCT02404701` - Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk	N/A
Completed	`NCT00283387` - Efficacy of Betaine for Reduction of Urine Oxalate in Patients With Type 1 Primary Hyperoxaluria	Phase 2
Completed	`NCT00587041` - Use of Oral Probiotics to Reduce Urinary Oxalate Excretion	Phase 1/Phase 2
Completed	`NCT04571359` - Spot Urine Oxalate to Creatinine Ratio and 24 Hours Urinary Oxalate
Withdrawn	`NCT00280215` - Renal Protective Effect of ACEI and ARB in Primary Hyperoxaluria	Phase 3