Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults

Energy Metabolism Clinical Trial

— IMS  

Official title:

Efecto de Una sesión de Ejercicio físico Realizada Durante un Periodo de Ayuno de 24-34 Horas Sobre el Metabolismo energético y la función Cognitiva en Adultos Sanos: Estudio Piloto

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05919979
• Other study ID #: GSD-2023-002
• Status: Recruiting
• Phase: N/A
• Start date: May 29, 2023
• Est. completion date: December 31, 2024

Study information

• Verified date: May 2024
• Source: Universidad de Granada
• Contact: Guillermo Sanchez Delgado, PhD
• Phone: +34665186487
• Email: gsanchezdelgado[@]ugr.es
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study explores the impact of high-intensity exercise during fasting on energy metabolism and cognitive function in healthy adults. Changes in respiratory exchange ratio, blood substances, and cognitive performance will be measured after 24 and 34 hours of fasting with and without exercise in a randomized crossover design.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: December 31, 2024
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• 18-40 years old.
• Body mass index: 18.5-30.0 Kg/m2.
• Stable body weight (5kg range within the last 3 months)
• Being able to consume all the food items provided as part of the study.
• Not having change the time zone or have shifted sleeping hours equivalent to more than 3 hours on the previous 2 weeks.

Exclusion Criteria:

• Diagnosed with any chronic condition that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
• Diagnosed with a chronic endocrine, digestive, rheumatic, neurological, cardiac, pulmonary, autoimmune, or infectious condition that affects energy metabolism.
• Presenting any signs or symptoms of illness that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
• Pregnant or breastfeeding.
• Using medications or supplements that may alter energy metabolism.
• Currently undergoing or having undergone any type of nutritional intervention or treatment in the past 3 months.
• Engaging in more than 5 hours per week of habitual moderate-to-vigorous cycling.
• Any other condition that, in the research team's opinion, discourages participation in the study.

Related Conditions & MeSH terms

• Energy Metabolism

Intervention

Behavioral:
• 34-hour fasting in sedentary conditions
Participants will fast for 34h after a standardized breakfast, refraining from physical activity.
• 34-hour fasting with high-intensity exercise
Participants will fast for 34h after a standardized breakfast, performing a high-intensity exercise session 6-10 hours aprox. after starting the fasting period.

Locations

Country	Name	City	State
Spain	Instiuto Mixto Universitario Deporte y Salud	Granada

Sponsors (1)

Lead Sponsor	Collaborator
Universidad de Granada

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Respiratory Exchange Ratio		24-hour after starting the fasting period
Secondary	Respiratory Exchange Ratio		34-hour after starting the fasting period
Secondary	Serum insulin concentration		24-hour after starting the fasting period
Secondary	Serum insulin concentration		34-hour after starting the fasting period
Secondary	Serum glucose concentration		24-hour after starting the fasting period
Secondary	Serum glucose concentration		34-hour after starting the fasting period
Secondary	Dimensional Change Card Sort Test (NIH toolbox)		24-hour after starting the fasting period
Secondary	Dimensional Change Card Sort Test (NIH toolbox)		34-hour after starting the fasting period
Secondary	List Sorting Working Memory Test (NIH toolbox)		24-hour after starting the fasting period
Secondary	List Sorting Working Memory Test (NIH toolbox)		34-hour after starting the fasting period
Secondary	Flanker Test (NIH toolbox)		24-hour after starting the fasting period
Secondary	Flanker Test (NIH toolbox)		34-hour after starting the fasting period