Parathyroidectomy in Endstage Renal Disease

Status Completed

Clinical Trial Summary

To test the hypothesis that total parathyroidectomy retards cardiovascular calcification, improves bone mineral density, reduces cardiac hypertrophy and arterial stiffening in end-stage renal disease patients on maintenance dialysis.

Clinical Trial Description

Secondary hyperparathyroidism (SHPT) in patients with end-stage renal disease contributes to increased cardiovascular morbidity and mortality via different mechanisms. Uncontrolled hyperparathyroidism is associated with left ventricular hypertrophy and has been implicated in the development of cardiac interstitial fibrosis and diastolic dysfunction. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00745719
Study type	Interventional
Source	The University of Hong Kong
Contact
Status	Completed
Phase	N/A
Start date	March 2007
Completion date	January 2012

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03023748` - Intravenous Paricalcitol in Chronic Hemodialysis Patients	Phase 4
Terminated	`NCT00776191` - Randomized Multicenter Cross-over Study to Compare the Effect of Physioneal 35 to 40 on the Protein Metabolism	Phase 4
Completed	`NCT00745914` - Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma) Agonist in Diabetic End-Stage Renal Disease Patients	N/A
Completed	`NCT02981706` - Comparison of AVF Versus AVG in Elderly Patients Starting Dialysis	N/A
Completed	`NCT02946229` - Data Collection for Next Generation Ultrasound Technology Development	N/A
Completed	`NCT02976246` - Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patients	Phase 4
Completed	`NCT02966028` - Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)	Phase 2
Recruiting	`NCT02957877` - LMWH Infusion as Anticoagulation for Home HD	Phase 4
Completed	`NCT03010072` - The Effect of Phosphate Lowering Using Sucroferric Oxyhydroxide (PA21) on Calcification Propensity of Serum	Phase 2
Recruiting	`NCT03020303` - Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease	Phase 3
Completed	`NCT00745589` - Sevelamer Hydrochloride in Peritoneal Dialysis Patients	N/A
Not yet recruiting	`NCT02976688` - Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis	Phase 2/Phase 3
Completed	`NCT02970201` - Improving Adherence in Renal Dialysis Patients Through Electronic Interventions	N/A
Withdrawn	`NCT00502268` - Vitamin D and Carboxy PTH Fragments in Coronary Calcification	Phase 4
Completed	`NCT02207153` - Risk Assessment by Cardiovascular Biomarkers in Chronic Dialysis Patients
Completed	`NCT02977117` - The Effect of Increasing Dialysate Magnesium on Calcification Propensity in Subjects on Haemodialysis	Phase 2
Completed	`NCT02866214` - Effect of Febuxostat on Endothelial Dysfunction in Hemodialysis Patients.	Phase 2/Phase 3
Not yet recruiting	`NCT03054454` - A Podiatry Led MDT Intervention to Reduce the Burden of Foot Disease in Patients With End Stage Kidney Failure	N/A