Effect of Febuxostat on Endothelial Dysfunction in Hemodialysis Patients.

Status Completed

Clinical Trial Summary

The Purpose of this study is to determine if the Febuxostat has an effect on endothelial dysfunction on hemodialysis patients.

Clinical Trial Description

Aim of The Work:

1- Evaluation of the effect of febuxostat on endothelial dysfunction in hemodialysis patients, through detection of:

1. Primary endpoint:

• Reduction in Asymmetrical Dimethylarginine (ADMA)

2. Secondary endpoints:

- Assessing the change in serum High sensitivity C-reactive protein (hsCRP)

- Assessing the change in serum Uric acid - The criteria for inclusion:

1. Outpatients on maintenance hemodialysis.

2. Age from 18-70 years old.

3. Serum UA level 7.0 mg/dL or more.

4. Stable clinical condition (no hospitalization in the previous 3 months)

The exclusion criteria:

1. Current urate-lowering therapy. (allopurinol, probenecid, bucolome, febuxostat)

2. History of hypersensitivity to febuxostat.

3. Current treatment with mercaptopurine, azathioprine, pyrazinamide, or ethambutol.

4. Participant in an another clinical trial within the past 4 weeks.

5. Judged to be unsuitable as a subject by the attending physician.

After two months , the patient will be reassessed regarding:

A. ADMA serum level. B. Change in serum hsCRP. C. Change in serum Uric acid level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02866214
Study type	Interventional
Source	Ain Shams University
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	August 2016
Completion date	October 2016

View Details

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