Intraoperative Simultaneous Pressure Guided Revascularization Study — INSTANT  

Blood Pressure Clinical Trial

Official title: Intraoperative Simultaneous Pressure Guided Revascularization Study

Status Completed

Clinical Trial Summary

This study aims to determine whether intraoperative physiologic measurements of blood flow to the leg during endovascular treatment of Peripheral Arterial Disease (PAD) can predict future clinical outcomes.

Clinical Trial Description

Lower extremity peripheral arterial disease (PAD) caused by atherosclerosis can cause cause leg pain, gangrene, and limb loss. PAD is a result of poor blood flow to the extremity, and the emerging most common initial method of interventional treatment is endovascular therapy, for example angioplasty or stenting. The poor blood flow to the extremity can be inferred by the hemodynamic pressure of blood in the leg. These toe or ankle pressure measurements are typically performed before surgery to diagnose PAD, and after surgery as surveillance.

However, endovascular treatment has a high failure rate often exceeding 20% within a year. There is evidence that physiologic measurements prior to treatment and after treatment are closely related to clinical outcomes. This study introduces these physiologic measurements to the operating room, to determine if physiologic improvement can be detected instantaneously during endovascular revascularization. Patients will be followed for a year following surgery to detect hemodynamic and clinical outcomes. The rationale of these intraoperative measurements would be to potentially guide future surgery, by providing real-time hemodynamic feedback to the operator. ;

Related Conditions & MeSH terms

• Blood Pressure
• Clinical Decision-Making
• Endovascular Procedures
• Monitoring, Intraoperative
• Peripheral Arterial Disease
• Peripheral Vascular Diseases
• Vascular Diseases

• NCT number: NCT03875846
• Study type: Observational
• Source: University of Ottawa
• Status: Completed
• Start date: October 1, 2018
• Completion date: January 1, 2021