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Endovascular Procedures clinical trials

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NCT ID: NCT05953623 Not yet recruiting - Clinical trials for Stroke, Acute Ischemic

Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients

Start date: August 1, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin through the implementation of a 3 + 3 dose-escalation design.

NCT ID: NCT05885178 Enrolling by invitation - Clinical trials for Stroke, Acute Ischemic

Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-1 (TRACK-LVO-1)

TRACK-LVO-1
Start date: January 1, 2018
Phase:
Study type: Observational

The aim of this study is to establish an academic, real-world, single-center, observational registry of consecutive patients hospitalized with acute ischemic stroke (AIS) due to large vessel occlusions (LVO), treated with either endovascular therapy (EVT) or best medical management (BMM).

NCT ID: NCT05851989 Recruiting - Clinical trials for Aneurysmal Subarachnoid Hemorrhage

Study on Prognosis of Acutely Ruptured Intracranial Aneurysms

SPARTA
Start date: July 14, 2021
Phase:
Study type: Observational

The SPARTA study is a prospective multicenter observational trial in the Netherlands with the aim of identifying the best clinical care in patients with aneurysmal subarachnoidal haemorrhage. Differences in outcome between surgical treatment and endovascular treatment will be explored. Furthermore, cost effectiveness and radiological prognostic factors will be examined.

NCT ID: NCT05659160 Recruiting - Clinical trials for Stroke, Acute Ischemic

Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-2

TRACK-LVO-2
Start date: November 1, 2021
Phase:
Study type: Observational [Patient Registry]

The objective of this study is to create a comprehensive, real-world, multi-center observational registry of consecutive patients admitted to hospitals with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), who are treated with either endovascular therapy (EVT) or the best available medical management (BMM).

NCT ID: NCT05653505 Not yet recruiting - Clinical trials for Ischemic Preconditioning

Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic Stenosis

Start date: January 1, 2023
Phase:
Study type: Observational [Patient Registry]

The purpose of this registry is to evaluate the safety and efficacy of RIC for patients with symptomatic intracranial atherosclerotic stenosis (sICAS) undergoing endovascular therapy.

NCT ID: NCT05257824 Recruiting - Clinical trials for Endovascular Procedures

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Start date: June 23, 2022
Phase: Phase 4
Study type: Interventional

Comparison of duration of dual antiplatelet therapy after stent-assisted coiling of unruptured intracranial aneurysms

NCT ID: NCT05049564 Completed - Clinical trials for Intracranial Aneurysm

Comparison of Clipping Via Keyhole Versus Traditional Approaches and Coiling for Ruptured Aneurysms

Start date: January 1, 2013
Phase: N/A
Study type: Interventional

Endovascular coiling has become a strategy of choice of intracranial aneurysms due to its minimally invasiveness. However, there has few prospective randomized controlled studies on the comparison of therapeutic effect between endovascular coiling and microsurgical clipping, especially the latter via keyhole approaches, which has been widely used in recent years. Based on the data of a single center, a randomized controlled study was conducted on patients with ruptured anterior circulation aneurysms suitable for both endovascular and extravascular treatment, including endovascular coiling, microsurgical clipping via conventional craniotomy and keyhole approaches, in order to compare the efficacy of the above strategies and provide more objective basis for treatment selection for operators.

NCT ID: NCT04854278 Recruiting - Patient Safety Clinical Trials

Introduction of an Operating Room Black Box to Identify, Analyse and Prevent Errors in the Vascular Hybrid Room

Start date: February 19, 2019
Phase:
Study type: Observational

The "OR Black box", an inclusive multiport data capturing system has been developed and successfully used for detailed analysis of laparoscopic surgical procedures. A pilot study has shown that this system can be successfully installed in the hybrid room at Ghent University Hospital and used for detailed analysis of intra-operative errors and radiation safety issues in endovascular procedures. Secondary analysis of pilot study data via direct video coding assessed the relationship between leadership style of the surgeon and team behavior and possible fluctuations during surgery. This novel approach allows a prospective objective assessment of human and environmental factors as well as measurement of errors, events and outcomes. In this study, the aim is to use the acquired knowledge to characterize a chain of events, identify high-risk interventions and identify areas for improvement, both on an organizational, team or individual level. Hypothesis: non-technical skills, environmental factors and teamwork in the hybrid room correlate with surgical technical performance and error rates. Furthermore, we hypothesize that incidents and adverse events can be tracked to a chain of errors that is influenced by technical and non-technical skills as well as environmental factors.

NCT ID: NCT04099615 Completed - Clinical trials for Endovascular Procedures

PROMISE (Somatosensory Evoked POtEntials MonItoring During Acute Ischemic StrokE) Study

PROMISE
Start date: January 1, 2018
Phase:
Study type: Observational [Patient Registry]

Endovascular treatment in patients with acute ischemic stroke due to large vessel occlusion does not always lead to good clinical and functional outcome, despite achieving complete arterial recanalization. The rate of significant functional disability or death after three months of an acute ischemic stroke still ranges from 40% to 67%. There is experimental and clinical evidence that somatosensory evoked potentials (SEPs) are good indicators of cerebral blood flow. The primary objective of this study is to determine the sensitivity and specificity of N20 response of SEPs prior to mechanical thrombectomy (MT) as a predictor of functional independence at 90 days after endovascular treatment. Secondly, the investigators will study whether SEPs may be neurophysiological markers of brain tissue in ischemic penumbra and optimal collateral circulation. Bilateral median nerve SEPs will be recorded before and continuously during MT in patients with acute ischemic stroke and anterior large vessel occlusion. N20 response ipsilateral to the cerebral hemisphere affected will be measured (qualitatively and quantitatively). The adjusted predictive value of the N20 biomarker on functional independence after MT will be analyzed by binary logistic regression and its predictive value on the full range of disability by ordinal logistic regression. The investigators will construct different regression models with other clinical predictors available at the prehospital setting and with those determined after hospital admission to determine the independent predictive power of the N20 response for a potential treatment decision-making. Finally, the investigators will study whether SEP can be neurophysiological markers ischemic penumbra tissue and optimal collateral circulation through its correlation with multimodal neuroimaging techniques. SEPs recording is non-invasive technique that can be performed at the bedside of the patient. The development of a portable device which could allow SEPs recording by sanitary staff (pre- and intrahospitally) would provide early data about N20 value, speeding up streamline decision making.

NCT ID: NCT03875846 Completed - Blood Pressure Clinical Trials

Intraoperative Simultaneous Pressure Guided Revascularization Study

INSTANT
Start date: October 1, 2018
Phase:
Study type: Observational

This study aims to determine whether intraoperative physiologic measurements of blood flow to the leg during endovascular treatment of Peripheral Arterial Disease (PAD) can predict future clinical outcomes.