Neuromuscular Blockade Clinical Trial
Official title:
Comparing Intubating Conditions and Hemodynamic Changes Between Macintosh Laryngoscopy and Bonfils Fibrescope During Endotracheal Intubation Without Neuromuscular Blockade
We studied intubating conditions and hemodynamic changes during endotracheal intubation employing either Bonfils intubating fiberscope or the conventional Macintosh laryngoscopy in 80 healthy patients candidates for elective surgery requiring endotracheal intubation. We omitted neuromuscular blocking drugs from the induction regimen.
BACKGROUND:
Neuromuscular blocking drugs (NMBDs) are believed to be the dominating antigens causing
bronchospasm and anaphylaxis during anaesthesia. Avoidance of these drugs, however, renders
compromised intubating conditions and higher morbidity with conventional Macintosh
laryngoscopy. Thus, we compared Macintosh laryngoscopy with Bonfils intubation fibrescope
without administering NMBDs.
METHODS:
Eighty male and female patients scheduled for elective surgery, aged 15 to 60 years, ASA
class II or I, non-obese, with lower risk for difficult intubation were enrolled in this
study. They were randomly allocated into the Bonfils group or the Macintosh group (40 each).
Following adequate hydration and preoxygenation, midazolam 0.05 mg kg-1 was administered,
followed by alfentanil 20 µg kg-1, lidocaine 1.5 mg kg-1, and propofol 2 mg kg-1
intravenously. Tracheal intubation was then carried out using Bonfils intubation fibrescope
(Bonfils group) or employing conventional Macintosh laryngoscopy (Macintosh group). The
primary outcome measure was the intubating condition, with mean arterial blood pressure and
heart rate as secondary outcomes.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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