Endothelial Dysfunction Clinical Trial
— CLEAROfficial title:
Subclinical Cardiovascular Health Benefits of Interventions to Reduce Exposure to Combustion-Derived Particulate Air Pollution
Verified date | April 2014 |
Source | Simon Fraser University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Canada: Canadian Institutes of Health Research |
Study type | Interventional |
This study is focused on the effects of HEPA filtration to reduce exposures to
combustion-derived air pollution (CDAP). Specifically, the study will evaluate the health
benefits of HEPA filters and compare the cardiovascular toxicity of two major sources of
CDAP, specifically traffic and residential wood combustion.
Specifically, the purpose of this study is to evaluate the ability of portable high
efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and air pollution
indoors and to improve subclinical indicators of microvascular function and systemic
inflammation among healthy adult participants.
The investigators hypothesize that HEPA filter use will help decrease indoor concentrations
of CDAP thereby helping to mitigate the associated cardiovascular risks.
Status | Completed |
Enrollment | 83 |
Est. completion date | August 2012 |
Est. primary completion date | August 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 19 Years and older |
Eligibility |
Inclusion Criteria: - 19 years or older - non-smoking household - lives within study boundaries and in areas of interest Exclusion Criteria: - COPD - asthma - diabetes - heart disease - hypertension - arthritis - gum disease - occupationally exposed to traffic exposures &/or woodsmoke - if female, pregnant |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Canada | Simon Fraser University | Burnaby | British Columbia |
Lead Sponsor | Collaborator |
---|---|
Simon Fraser University |
Canada,
Allen RW, Carlsten C, Karlen B, Leckie S, van Eeden S, Vedal S, Wong I, Brauer M. An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community. Am J Respir Crit Care Med. 2011 May 1;183(9):1222-30. doi: 10.1164/rccm.201010-1572OC. Epub 2011 Jan 21. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Difference in reactive hyperemia measurement after HEPA filtration | Participants endothelial function are tested after 1 week of HEPA filtration and after 1 week of non-HEPA filtration (placebo filtration). | after 1 week of filtration | No |
Secondary | Difference in C-Reactive Protein after HEPA Filtration | Participants CRP is measured after 1 week of HEPA filtration and after 1 week of non-HEPA filtration (placebo filtration). | after 1 week of filtration | No |
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