The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Endothelial Dysfunction Clinical Trial

Official title:

The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00358306
• Other study ID #: F070309010
• Status: Completed
• Start date: April 2008
• Est. completion date: July 2009

Study information

• Verified date: May 2020
• Source: University of Alabama at Birmingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Description:

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: July 2009
• Est. primary completion date: July 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 2 Years to 20 Years

Eligibility

Inclusion Criteria:

• Children between age 2-20

• Decrease in renal function by 25% or greater

• Renal function has returned to normal

Exclusion Criteria:

• History of chronic disease

• Cancer

• Congenital heart disease

• Organ Transplantation

• Liver disease

• Pulmonary disease

• Diabetes other primary metabolic condition

• Severe neurologic impairments

• Hypertension

• Auto-immune

• Infectious disease or renal disease

• Smokers

• Renal disease w/primary cause i.e. - HUS or Glomerulonephritis

• severe allergies including allergy to seafood and/or iodine

Related Conditions & MeSH terms

• Acute Kidney Injury
• Acute Renal Failure
• Chronic Kidney Failure
• Endothelial Dysfunction
• Hemolysis
• Hemolytic-Uremic Syndrome
• Hemolytic-uremic Syndrome (HUS)
• Kidney Diseases
• Kidney Failure, Chronic
• Renal Insufficiency
• Renal Insufficiency, Chronic

Locations

Country	Name	City	State
United States	University Of Alabama	Birmingham	Alabama

Sponsors (1)

Lead Sponsor	Collaborator
University of Alabama at Birmingham

Country where clinical trial is conducted

United States,