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Endothelial Cell Loss, Corneal clinical trials

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NCT ID: NCT05587205 Recruiting - Cataract Clinical Trials

Study to Assess Safety and Tolerability of EO2002

Start date: December 1, 2022
Phase: Phase 1
Study type: Interventional

The goal of this clinical study is to assess the safety of intracameral injection of EO2002 in subjects post-cataract surgery.

NCT ID: NCT05529485 Completed - Cataract Clinical Trials

Quantification of Factors Influencing Endothelial Damage During Phacoemulsification

PREDICSPILOT
Start date: January 12, 2022
Phase:
Study type: Observational

The aim of this study is to determine the principal factors that influence endothelial cell loss three month post cataract surgery. Methods: Multi center observational Cohort study, inclusion period from 12/01/2022 to 10/06/2022. One hundred and seventy-five eyes of hundred and four patients who have appointment for cataract surgical indication were included. The percentage of corneal endothelial cell loss was quantified using specular microscopy before and 3 months after the surgery. 14 variables (pre-operative and intra-operative) that could be associated to endothelial cell injury were selected. A bivariate analysis of relationship between these factors and endothelial cell loss at 3 months was performed by simple linear regression (Wilcoxon and Fischer tests). Multivariate analysis was performed by multiple linear regression in order to identify the factors independently related to endothelial cell loss.

NCT ID: NCT05194891 Not yet recruiting - Clinical trials for Endothelial Cell Loss, Corneal

Endothelial Changes in Pseudoexfoliation Syndrome

PEX
Start date: February 1, 2022
Phase:
Study type: Observational

this study aimed to evaluate the corneal endothelial cell changes before and after phacoemulsification in pseudoexfoliative patients relative to healthy adults.

NCT ID: NCT04547036 Completed - Glaucoma Clinical Trials

Changes in Corneal Endothelial Cell Density After Transscleral ab Interno Glaucoma Gel Stent Implantation

Start date: January 30, 2020
Phase:
Study type: Observational

The objective of this study is to evaluate the change of endothelial cell count after XEN45 in patients with or without cataract operation.

NCT ID: NCT03855293 Completed - Clinical trials for Endothelial Cell Loss, Corneal

Protecting the Corneal Endothelium During Cataract Surgery Using the Anterior Capsule

Start date: March 2, 2016
Phase: N/A
Study type: Interventional

Cataract surgery is one of the most frequently performed surgical procedures worldwide. Since the introduction of phacoemulsification to remove the cataractous lens, risk and complication rates of cataract surgery decreased significantly. The phacoemulsification technique utilizes a high-intensity ultrasound energy for the fragmentation and emulsification of the lens. One of the main complications during phacoemulsification, is damaging of the endothelium due to contact with lens fragments of the nucleus following turbulent flow of irrigating solution, resulting in corneal damage, inflammation of the endothelium and corneal edema. In this study we want to evaluate the effect of the anterior capsule, gained by capsular rhexis, as a corneal shield during phacoemulsification on the corneal endothelium.