Platelet-rich Plasma Clinical Trial
Official title:
Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection
In Korea, where the prevalence of gastric tumors is high, the use of ESD as a treatment for gastric cancer will continue to increase. Considering that there are no special measures to prevent side effects (bleeding, perforation, etc.) of this procedure, it is possible to reduce the large medical costs through the discovery of substances that can promote gastric mucosal healing. Mechanism of PRP-based materials in the regeneration of gastric mucosal damage can be used to understand the pathophysiology of ulcers. In the future, it can be suggested as a new treatment for gastrointestinal tract damage such as intractable ulcer, perforation, mucosal fistula, gastrointestinal bleeding caused by esophagus, small intestine and large intestine as well as ulcer treatment by endoscopic procedure.
Background:In Korea, where the prevalence of gastric tumors is high, the use of ESD as a
treatment for gastric cancer will continue to increase. Considering that there are no special
measures to prevent side effects (bleeding, perforation, etc.) of this procedure, it is
possible to reduce the large medical costs through the discovery of substances that can
promote gastric mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in
preclinical endoscopic resection models.
Aim: Evaluate the efficacy of PRP on participants submitted to ESD.
Material and Methods: The investigators have evaluated a prospective clinical study. The
investigators have included 10 participants submitted to ESD. Patients were informed and
accepted to participate with a written consent. Prior to endoscopy PRP was obtained from
autologous blood with a commercial kit. Resection was performed with standard technique.
Immediately after the procedure, autologous PRP is applied to the artificial gastric ulcer
using endoscopic spray. Participants were followed-up after the procedure.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT05483634 -
Compare Vaginal Estrogen and Platelet-rich Plasma Over Women With Genitourinary Syndrome of Menopause
|
||
Not yet recruiting |
NCT05096650 -
Platelet Rich Plasma for Treatment of Facial Photoaging: A Double-blind, Randomized, Split-face Study
|
N/A | |
Completed |
NCT03667638 -
Influence of Platelet Concentrates on Wound Healing
|
N/A | |
Recruiting |
NCT04972331 -
Degenerative Meniscus Without Osteoarthritis : Arthroscopic Partial Menisectomy Versus Platelet Rich Plasma (APM-PRP)
|
N/A | |
Recruiting |
NCT06440655 -
The Efficacy and Safety of Platelet-rich Fibrin and Platelet Rich Plasma in Female Pattern Hair Loss Patients
|
N/A | |
Completed |
NCT04351087 -
Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis: a Randomized Comparative Trial
|
N/A | |
Completed |
NCT03197428 -
Platelet-rich Plasma for Chronic Lateral Ankle Instability
|
N/A | |
Recruiting |
NCT04040283 -
Platelet-rich Plasma for Menical Tear
|
||
Not yet recruiting |
NCT03859843 -
Efficacy and Antimicrobial Activity of Platelet Rich Plasma (PRP) in Acne Vulgaris
|
Phase 3 | |
Completed |
NCT05585216 -
The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq
|
N/A | |
Completed |
NCT05925829 -
Stromal Vascular Fraction and Autologous Activated Platelet-Rich Plasma Combination in Treating Treatment of Type 2 Diabetes
|
Phase 1 | |
Completed |
NCT04350827 -
PRP vs PRP Plus IGF for Patellar Tendinosis
|
N/A | |
Completed |
NCT04522674 -
Platelet-Rich Plasma (PRP) for Treatment of Symptomatic Lumbar Facet Syndrome of the Spine
|
Early Phase 1 | |
Not yet recruiting |
NCT03779945 -
Effect of Platelet-Rich-Plasma in Spine Fusion
|
Phase 4 | |
Completed |
NCT03197441 -
Platelet Rich Plasma for Knee Osteoarthritis
|
N/A | |
Completed |
NCT03176641 -
Platelet-rich Plasma for Meniscus Repair
|
N/A | |
Completed |
NCT02931149 -
Evaluation of the Efficacy of Platelet-rich Plasma (PRP) on Advanced Endoscopic Resection Techniques
|
Phase 3 | |
Recruiting |
NCT05230667 -
Comparison of the Effect of Combined Glenohumeral Joint and Subdeltoid Bursa Injection With Platelet-rich Plasma (PRP), Corticosteroid, and Normal Saline in Addition to Physical Therapy for Treatment of Frozen Shoulder
|
N/A | |
Completed |
NCT03197415 -
Platelet-rich Plasma for Low Back Pain
|
N/A |