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Endoscopic Submucosal Dissection clinical trials

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NCT ID: NCT05736705 Not yet recruiting - Esophageal Neoplasm Clinical Trials

Monopolar and Bipolar in Esophageal ESD

Start date: March 31, 2024
Phase: N/A
Study type: Interventional

The objective of this study is to prospectively document the efficacy and clinical outcomes of Endoscopic Submucosal Dissection procedure that utilize either a novel Bipolar-Current ESD device or the standard monopolar electrocautery knife.

NCT ID: NCT05407870 Recruiting - Clinical trials for Sedation Complication

Efficacy and Safety of Etomidate Sedation in Gastric Endoscopic Submucosal Dissection

Start date: June 9, 2022
Phase: N/A
Study type: Interventional

During endoscopy, the patient is sedated to relieve pain and improve the ease of the procedure. Sedation endoscopy using propofol is effective, but has the disadvantage that cardiopulmonary side effects are frequently observed. However, etomidate is known to have hemodynamic and respiratory stability.The purpose of this study was to compare the efficacy and safety of etomidate and propofol in sedated gastric endoscopic submucosal dissection.

NCT ID: NCT05323929 Recruiting - Clinical trials for Early Gastric Cancer

The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

This study is a single-center, prospective, group-controlled clinical trial, aiming to clarify the relationship between the depth of dissection and scar formation in the treatment of early gastric cancer by ESD, and to provide high-quality evidence-based medicine for the treatment of early gastric cancer.

NCT ID: NCT05265221 Completed - Gastric Neoplasm Clinical Trials

Learning Curve for Gastric Endoscopic Submucosal Dissection

Start date: March 1, 2022
Phase:
Study type: Observational

Endoscopic submucosal dissection (ESD) for early gastric cancer is a widely accepted treatment option of expanded indication worldwide. ESD is relatively difficult compared with endoscopic mucosal resection, thus, proper training is essential for the safe performance of the procedure. Thus, it is necessary to receive proper training in the procedure for safe performance of ESD. Previous studies reported that there was a learning curve in ESD training and preceptees needed to perform at least 30-40 procedures in order to master this technique. However, there is few study about the association between the clinical characteristics and competence level for gastric ESD.

NCT ID: NCT04780256 Recruiting - Clinical trials for Esophageal Neoplasms

Endoscopic Resection of Gastrointestinal Neoplasms

Start date: March 15, 2021
Phase:
Study type: Observational

The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare different resection techniques. In particular, the resection techniques investigated will be mucosectomy, en bloc and piecemeal, endoscopic submucosal dissection (ESD) and its variants, full-thickness resection. The anatomical districts involved will be the esophagus, stomach, duodenum, colon and rectum.

NCT ID: NCT04482491 Completed - Clinical trials for Endoscopic Submucosal Dissection

Histological Prediction and Choice of the Resection Strategy in Front of a Colorectal Lesion > 2 cm: Prospective Comparison of Endoscopic Characterization, Non-targeted and Targeted Biopsies

Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

Colorectal cancer has become a public health priority considering its increased prevalence and high mortality rate when diagnosed late. As a consequence, many countries have promoted and uptaken of colorectal cancer screening programs leading to an increasing detection of advanced but also superficial lesions ESGE (European Society of Gastrointestinal Endoscopy) guidelines states that the majority of those colonic and rectal superficial lesions can be removed in a curative way by standard polypectomy and/or by EMR (Endoscopic Mucosal Resection) and that ESD (Endoscopic Submucosal Dissection) can be considered for removal of colonic and rectal lesions with high suspicion of limited submucosal invasion. Histologically, a resection is curative for the patient when the adenocarcinoma is well-differentiated (G1/G2), with a depth of invasion ≤ sm1 (≤ 1 mm submucosal invasion), with no lymphovascular invasion nor budding and with lateral and deep margins free of cancer

NCT ID: NCT03220334 Completed - Clinical trials for Platelet-rich Plasma

Healing Effects of Autologous Platelet Rich Plasma on Gastric Ulcer Caused by Endoscopic Submucosal Dissection

Start date: June 1, 2017
Phase: Phase 3
Study type: Interventional

In Korea, where the prevalence of gastric tumors is high, the use of ESD as a treatment for gastric cancer will continue to increase. Considering that there are no special measures to prevent side effects (bleeding, perforation, etc.) of this procedure, it is possible to reduce the large medical costs through the discovery of substances that can promote gastric mucosal healing. Mechanism of PRP-based materials in the regeneration of gastric mucosal damage can be used to understand the pathophysiology of ulcers. In the future, it can be suggested as a new treatment for gastrointestinal tract damage such as intractable ulcer, perforation, mucosal fistula, gastrointestinal bleeding caused by esophagus, small intestine and large intestine as well as ulcer treatment by endoscopic procedure.

NCT ID: NCT03039309 Recruiting - Clinical trials for Endoscopic Submucosal Dissection

Endoscopic Submucosal Dissection for Early GI Neoplasia in the United Kingdom

ESDUK
Start date: August 5, 2016
Phase:
Study type: Observational [Patient Registry]

Multicentre cohort study on the use of endoscopic submucosal dissection for the treatment of early gastrointestinal neoplasia.

NCT ID: NCT02989818 Recruiting - Clinical trials for Endoscopic Submucosal Dissection

Multi-center Evaluation of the Clinical Utility of ESD in the Western Population

Start date: March 2016
Phase:
Study type: Observational

The aim of this multi-center study is to prospectively document the clinical utility of ESD.

NCT ID: NCT02931149 Completed - Clinical trials for Platelet-rich Plasma

Evaluation of the Efficacy of Platelet-rich Plasma (PRP) on Advanced Endoscopic Resection Techniques

Start date: August 2016
Phase: Phase 3
Study type: Interventional

To avoid complications secondary to advanced endoscopic resection techniques (Endoscopic Mucosal Resection -EMR- or Endoscopic Submucosal Disection -ESD-) the endoscopists have to avoid deep thermal damage and increase mucosal healing. Platelet-rich plasma (PRP) has demonstrated efficacy in preclinical endoscopic resection models.