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NCT01496794 Clinical Trial

Endophthalmitis Cultures

Endophthalmitis Clinical Trial

— PROSPER  

Official title:
Prospective Surveillance of Patients With Endophthalmitis for Multi-antibiotic Resistance (PROSPER) Study

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT01496794
Other study ID # 100487
Secondary ID
Status Terminated
Phase N/A
First received December 19, 2011
Last updated February 20, 2017
Start date October 2011
Est. completion date April 2016

Study information
Verified date February 2017
Source Vanderbilt University Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin and ceftazidime) versus combination therapy with vancomycin, ceftazidime, and moxifloxacin.

Research hypothesis:

1. Cultured bacterial isolates will demonstrate faster in vitro sterilization rates with combination treatment (vancomycin, ceftazidime, and moxifloxacin) compared to "standard therapy" with vancomycin and ceftazidime.

2. Longitudinal analysis of resistance patterns of cultured isolates will show increasing rates of multi-antibiotic resistance.

Description:

Adult patients over 18 years of age presenting with endophthalmitis and able to sign consent.

Recruitment information / eligibility
Status Terminated
Enrollment 3
Est. completion date April 2016
Est. primary completion date April 2016
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- all adult patients age 18 or greater presenting with bacterial endophthalmitis to the Vanderbilt Eye Institute and who grow positive cultures

Exclusion Criteria:

- Patients < 18 years of age or those patients without positive cultures

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United States Vanderbilt Eye Institute Nashville Tennessee

Sponsors (1)
Lead Sponsor Collaborator
Vanderbilt University

Country where clinical trial is conducted

United States, 

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