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Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer

Endometrial Neoplasms Clinical Trial

Official title:
Cohort Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer

Clinical Trial Summary

In patients diagnosed as endometrial cancer by thorough pathologic examinations, Lynch syndromes are screened by (1)immunohistochemical staining (for MLH1, MSH2, MSH6 and PMS2), (2) tests of microsatellite instability and (3) clinical criteria (Amsterdam I or II criteria and Bethesda criteria). For patients with any suspicious discoveries of Lynch syndromes from aforementioned screening methods, a molecular diagnosis with next-generation sequencing for mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) is given to confirm Lynch syndromes. For patients of Lynch syndromes and endometrial cancer, relatives of blood lineage are tested by Sanger method or qPCR to find out carriers of mutation genes of Lynch syndromes.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03291106
Study type Observational
Source Peking Union Medical College Hospital
Contact Lei Li, MD
Phone 13911988831
Email lileigh@163.com
Status Recruiting
Phase
Start date September 1, 2017
Completion date October 1, 2020
View Details
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