Irreversible Pulpitis Clinical Trial
Official title:
Clinical Study: Evaluation of the Antibacterial Effect of Insoluble Antibacterial Nanonparticles Incorporated in Dental Materials for Endodontic Treatment
The effect of Antibacterial Nanoparticles, Incorporated in root canal sealer material and in provisional restoration is going to be examined. Two different tests are planned: (1) clinical and radiological evaluation of root canal sealer.(2) An evaluation in the laboratory the efficacy of provisional restoration during root canal treatment.We assume, based on our previous laboratory studies that show antibacterial properties, that the incorporation of the nanoparticels will improve the treatment outcome.
1. patients with molar teeth diagnosed with healthy pulp or irreversible pulpitis, and
need root canal treatment, will be asked to participate in the study. After cleaning
the teeth following a standard protocol, a sterile cotton wool will be placed in the
pulp chamber. provisional restoration with (test group-40 patients) and without
(control group- 40 patients) nanoparticles will seal the teeth between apointments.
After a month the cotton wool will be taken out and tansferred to the laboratory. The
root canal treatment will continue following the standard protocol.
2. patients with single canal teeth diagnosed with infected pulp and periapical lesion,
and need root canal treatment, will be asked to participate in the study. Two study
group (40 patients on each group) will have their canal sealed with a two types of
endodontic sealers each + the nanoparticles. The control group (40 patients) will have
their canal sealed with the conventional sealer alone. The patients will be invited to
4 follow ups: 2 weeks, 3 months, 6 months and 1 year during which a clinical and
radiological examinations will be performed.While preparing the post, a small example
of the sealer will be taken to a test in the lab.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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