Endocarditis Clinical Trial
Official title:
The Value of 99mTc-Leukoscan® Scintigraphy in the Diagnosis of Infectious Endocarditis on Surgical Materials
Infectious endocarditis is a serious pathology with difficult diagnosis especially on
prosthetic valves or cardiac device because of the plurality of clinical presentations and
the low sensitivity value of echocardiography in these patients. Despite a well validated
indication for the detection of septic emboli, the value of FDG-PET for the detection of
prosthetic valves or cardiac implantable device is still unclear especially because of
frequent non-septic inflammatory processes.
To improve the specificity value, the use of radio-labeled leukocytes scintigraphy is
conventionally proposed. An alternative method is to label leukocytes in vivo with an
anti-murin anti body fragment ( Sulesomab , Leukoscan®). This scintigraphy is regularly used
in the investigation of osteomyelitis and has been proposed in infectious endocarditis. To
knowledge of investigators, the value of Leukoscan® scintigraphy on prosthetic valve or
cardiac device infection had not been studied.
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