End-stage Renal Disease Clinical Trial
Official title:
The Role of Hepcidin as a Biomarker to Predict Successful Renal Transplantation
High hepcidin concentrations indicate that iron is blocked from secretion from the reservoir.
Hepcidin may be useful in prediction functional iron utilization in renal failure patients.
Hepcidin is also associated with chronic renal failure and residual renal function in
dialysis patients. Recent studies have shown that hepcidin is a potential marker of impaired
renal function in a rat model of chronic nephropathy.
The purpose of this study was to investigate the relationship between preoperative hepcidin
levels and the incidence of success rate of kidney transplantation in patients with end-stage
renal failure undergoing kidney transplantation surgery. The study is a prospective
single-group observational study that analyzes hepcidin as a biomarker.
POD-1 : Researchers will meet patients scheduled for surgery and explain the study. (enroll)
the operation date : The patient will sign the consent form. Researchers will collect the
blood sample from the patient for testing hepcidin during the operation and record laboratory
data performed before surgery POD 1: laboratory test discharge date : laboratory test 6
months after surgery ; Researchers will determine the graft failure of the patient.
* laboratory test ; reticulocyte count, Hb, plasma hepcidin, iron profiles (serum iron, serum
ferritin, total iron-binding capacity, transferrin, transferrin saturation), coagulation
profiles (PT, PTT), routine urinary analysis, and chemical profiles (aspartate
aminotransferase (AST)/alanine aminotransaminase (ALT), serum creatinine, electrolytes,
C-reactive protein (CRP), estimated glomerular filtration rate (GFR)), ESR, cystatin C, NGAL,
pro BNP, troponin T and urinary analysis
;
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