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Effect of Vitamin K 2 on Vascular Calcification in Hemodialysis Patients

End Stage Renal Disease Clinical Trial

Official title:
The Impact of Vitamin K2 and Inactive Vitamin D Supplementation on Vascular Calcification in Pediatric Patients on Regular Hemodialysis

Clinical Trial Summary

The aim of this study is to assess the effect of supplementation of vitamin K2 (menaquinone, MK-7) and cholecalciferol (inactive vitamin D) on circulating levels of calcification regulators and to assess their safety in pediatric patients on regular hemodialysis patients.

Clinical Trial Description

Vascular calcification occurs in more than half of chronic renal failure patients, which mainly appears in the large and medium size arteries [3, 4]. It seems that vas¬cular calcification is caused by dynamic imbal-ance of intravascular calcium and phosphorus. However, more and more studies pointed out that vascular calcification were related with local cell's function and biological characteris¬tics.

The aim of this study is to assess the effect of supplementation of vitamin K2 (menaquinone, MK-7) and cholecalciferol (inactive vitamin D) on circulating levels of calcification regulators and to assess their safety in pediatric patients on regular hemodialysis patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04145492
Study type Interventional
Source Ain Shams University
Contact
Status Recruiting
Phase Phase 2/Phase 3
Start date September 1, 2019
Completion date February 1, 2020
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