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Impact of Dialysis Modality on Hepcidin and Iron Metabolism — HERMES  

End-stage Renal Disease Clinical Trial

Official title:
A Prospective, Multicenter, Observational Study to Evaluate the Impact of Peritoneal Dialysis Compared With Hemodialysis on Iron Metabolism and Hepcidin

Clinical Trial Summary

- Dialysis modality may influence the oxidative stress and proinflammatory cytokines in ESRD patients.

- Dialysis modality may affect hepcidin

- Dialysis modality may influence iron and ESA requirements.

Clinical Trial Description

It has been considered that PD patients tended to be less anemic and require lower ESA dose than HD patients. In addition, it was also known that the level of oxidative stress and inflammatory cytokines tended to be lower in PD patients than HD patients. And hepcidin synthesis is markedly increased during inflammation. Altogether, Lower ESA requirement in PD patients may be associated with lower hepcidin level due to lower inflammatory state compared with HD patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01723111
Study type Observational
Source Kyungpook National University
Contact
Status Completed
Phase N/A
Start date November 2012
Completion date August 2016
View Details
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