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The Measurement of Insulin Resistance in Peritoneal Dialysis Patients

End Stage Renal Disease Clinical Trial

Official title:
The Measurement of Insulin Resistance in Peritoneal Dialysis Patients

Clinical Trial Summary

The goal of this study is to examine the relevance of insulin resistance in peritoneal dialysis (PD) patients as well as the means to improve this metabolic derangement. We will do so through a prospective randomized study using Icodextrin as an alternate dialysate solution to routine glucose-based dialysate. We hypothesize that (1) the glucose loading associated with PD leads to impairment in insulin sensitivity, (2) the degree of insulin resistance is dependent on the basal metabolic state (fasting versus stimulated), and (3) the replacement of conventional dialysate with glucose-sparing dialysate preparations will improve insulin resistance and associated metabolic disturbances in PD patients.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01119196
Study type Interventional
Source Vanderbilt University
Contact
Status Completed
Phase N/A
Start date September 2010
Completion date January 2015
View Details
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