End Stage Renal Disease Clinical Trial
Official title:
Comparative Effects of Milk Thistle Extract With Vitamin-E on Oxidative Stress Biomarkers in Hemodialysis Patients
For end-stage renal disease (ESRD) patients, cardiovascular disease remains the single most
common cause of excess morbidity and mortality. Among the examined nontraditional risk
factors, an increase in oxidative stress as well as inflammation are postulated to
contribute to excessive cardiovascular risk in this population.
Flavonoids are naturally occurring substances that possess various pharmacological actions
and therapeutic applications. Some due to their phenolic structures have antioxidant effect
and inhibit free radical-mediated processes, as well as anti-inflammatory effects.
Silymarin,a mixture of three isomeric flavonolignans, is isolated from milk thistle (Silybum
marianum) seeds, and is proven to have anti-oxidant, anti-inflammatory, cell regenerating,
and antifibrotic action.
In this study, the effect of silymarin on oxidative stress and inflammation (2 major risk
factors for cardiovascular morbidity and mortality in hemodialysis patients)is evaluated,
and compared to vit E, a well known antioxidant.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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