End Stage Liver Diseases Clinical Trial
Official title:
Observational Study to Analyze Respiratory System Mechanics Changes and Inflammatory Responses During Orthotopic Liver Transplantation (SPPLIT Trial)
During orthotopic liver transplantation (OLT), respiratory system function may be severely
impaired for several reasons including anaesthesia effects, hyperdynamic volume state with
fluid overload and ischemia reperfusion injury. In particular, reperfusion syndrome is
characterised by the release of several inflammatory mediators such as cytokines and oxygen
free radicals which may contribute to alveolar endothelial barrier dysfunction. The object
of this study is to investigate the respiratory system mechanics impairment in its
partitioning between lung and chest wall.
We hypothesize that impairment of respiratory system mechanics (of both lung and chest wall)
occurs after reperfusion phase of liver. This impairment is associated with the systemic
inflammatory response following liver reperfusion.
n/a
Observational Model: Case-Only, Time Perspective: Prospective