End Stage Liver DIsease Clinical Trial
Official title:
Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease
A phase I trial to study the safety of mobilization of stem cells with G-CSF and Mozobil in patients with chronic liver disease.
Liver cirrhosis in humans represents the end stage of chronic liver injury. Supply of "new"
stem cells to the liver could regenerate hepatocytes and restore the lost function. Delivery
of Mesenchymal Stem Cells (MSCs) has been shown in animal models and limited clinical trials
to result in improved liver disease (MELD) score.
In preclinical studies we have demonstrated that the combination of G-CSF plus Mozobil can
effectively mobilize both hematopoietic stem cells (HSCs) and MSCs into the peripheral
circulation. While G-CSF only mobilizes HSCs.
The clinical trial will test the safety of treating patients with end stage liver disease
with G-CSF and Mozobil to mobilize MSCs into the peripheral circulation.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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