End Stage Liver DIsease Clinical Trial
Official title:
Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease
A phase I trial to study the safety of mobilization of stem cells with G-CSF and Mozobil in patients with chronic liver disease.
Liver cirrhosis in humans represents the end stage of chronic liver injury. Supply of "new"
stem cells to the liver could regenerate hepatocytes and restore the lost function. Delivery
of Mesenchymal Stem Cells (MSCs) has been shown in animal models and limited clinical trials
to result in improved liver disease (MELD) score.
In preclinical studies we have demonstrated that the combination of G-CSF plus Mozobil can
effectively mobilize both hematopoietic stem cells (HSCs) and MSCs into the peripheral
circulation. While G-CSF only mobilizes HSCs.
The clinical trial will test the safety of treating patients with end stage liver disease
with G-CSF and Mozobil to mobilize MSCs into the peripheral circulation.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03557086 -
A Randomized Controlled Trial of an Advanced Care Planning Video Decision Support Tool for Patients With End-Stage Liver Disease
|
N/A | |
| Completed |
NCT04604860 -
Use of EL-FIT App to Promote Physical Activity
|
N/A | |
| Completed |
NCT01933789 -
Improving Communication About Serious Illness
|
N/A | |
| Recruiting |
NCT01728727 -
Safety and Efficacy of Human Umbilical Cord Derived Mesenchymal Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01728688 -
Safety and Efficacy of Human Autologous Peripheral Blood Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01724697 -
Safety and Efficacy of Human Bone Marrow Stem Cells for Treatment of HBV-related Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT01412593 -
Intra-hepatic Artery Bone Marrow Derived Stem Cells Infusion for the Treatment of Advanced Liver Cirrhosis
|
Phase 1/Phase 2 | |
| Completed |
NCT00374582 -
End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
|
N/A | |
| Completed |
NCT00249652 -
Transplant and Addiction Project (TAP) - 1
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05998330 -
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
|
N/A | |
| Completed |
NCT04546048 -
The Early Strength Training Program in Post-transplant Liver Cases
|
N/A | |
| Active, not recruiting |
NCT03580629 -
Pilot Study of the Liver Live Donor Champion Program
|
N/A | |
| Recruiting |
NCT04037995 -
Real World Study of End-stage Liver Disease in China
|
||
| Recruiting |
NCT03870568 -
Functional Assessment in Liver Transplantation
|
||
| Recruiting |
NCT03633812 -
Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation
|
||
| Active, not recruiting |
NCT02889094 -
French HIV-HBV Cohort
|
||
| Completed |
NCT02444273 -
The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital
|
N/A | |
| Not yet recruiting |
NCT06069050 -
SALT in Adolescents With End-stage Liver Disease
|
N/A | |
| Recruiting |
NCT03228290 -
Functional Assessment in Liver Transplantation
|
||
| Recruiting |
NCT04107883 -
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
|
N/A |