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Mental Effects of Analgesic Drugs: Paracetamol and Ibuprofen — MEAD  

Empathy Clinical Trial

Official title:
Double Blinded Randomized Placebo Controlled Study on Mental Effects of Analgesic Drugs

Clinical Trial Summary

The objective of the present study is to study paracetamol effects on social pain and empathy under standardized international conditions (ICH-GCP) for planning, conduction and reporting of clinical pharmaceutical studies in humans. The study included MRI imaging of brain activity, analysis of genomic biomarkers potentially explaining interindividual variation. It is controversial whether the effects are of immediate nature or develop during a period of about 10 days. Therefore, the study is separated into two study phases. Single dosing (SD) is applied in study phase 1 and multiple-dosing (MD) in study phase 2. The study compares paracetamol with placebo and in the study phase 1 also with ibuprofen as analgetically active control.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04424420
Study type Interventional
Source University of Göttingen
Contact Jürgen Brockmöller, Prof.
Phone +49 (0) 551 39-53 11
Email jbrockm@gwdg.de
Status Recruiting
Phase Phase 1
Start date November 7, 2019
Completion date December 2021
View Details
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