Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03384030
Other study ID # NL62290.041.17
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 31, 2017
Est. completion date March 17, 2018

Study information

Verified date December 2017
Source NIZO Food Research
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In the MOIST study it will be assessed whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce malodor formation by emotional stress, as assessed by expert assessments of stress-induced malodor formation in the armpits of 30 healthy male volunteers.

Before, during and after being exposed to the adapted version of the STMST, saliva will be collected to determine cortisol levels, subjects have to rate their momentary feelings of anxiety and embarrassment and heart rate variability will be monitored continuously with a wireless signal transmission device. Before and after exposure to the adapted STMST, malodor levels will be assessed by two expert judges, axillary volatiles will be collected by cup scrubbing and microbiota samples will be taken to determine microbial species.


Description:

Stress is a primary physiological response to physical and/or social threats resulting from a complex interplay of neurophysiological and psychological factors. Cognitive interpretations of social-evaluative threats have been found to be very potent emotional stressors. Apocrine sweat glands are stimulated by emotional stress, fear or mental tension. Upon secretion, apocrine sweat is odorless. By enzymatic action of the bacterial microbiome on apocrine sweat in particular, body malodor is formed. This is perceived as offensive by most societies. As a result, self-confidence and social relationships can be influenced by undesired body odor. A good understanding of the complex sweat-microbiome interactions leading to malodor formation is required for the development of effective malodor remedies.

In the MOIST study it will be assessed whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce malodor formation by emotional stress, as assessed by expert assessments of stress-induced malodor formation in the armpits of 30 healthy male volunteers.

Before, during and after being exposed to the adapted version of the STMST, saliva will be collected to determine cortisol levels, subjects have to rate their momentary feelings of anxiety and embarrassment and heart rate variability will be monitored continuously with a wireless signal transmission device. Before and after exposure to the adapted STMST, malodor levels will be assessed by two expert judges, axillary volatiles will be collected by cup scrubbing and microbiota samples will be taken to determine microbial species.


Recruitment information / eligibility

Status Completed
Enrollment 30
Est. completion date March 17, 2018
Est. primary completion date November 17, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 34 Years
Eligibility Inclusion Criteria:

1. Male;

2. Age 18-34 yrs;

3. BMI between 18,5-25 kg/m2;

4. Healthy as assessed by the NIZO lifestyle and health questionnaire;

5. Non-smoking;

6. Signed informed consent;

7. Malodor score = 4= 8 as assessed by malodor judges

8. Access to internet;

9. Voluntary participation;

10. Willing to accept disclosure of the financial benefit of participation in the study to the authorities concerned;

11. Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for the study for at least 15 years;

12. Willing to accept information-transfer concerning participation in the study, or information regarding health, like laboratory results, findings at anamnesis or physical examination and eventual adverse events to and from his general practitioner;

13. Willing to comply with study procedures.

Exclusion Criteria:

1. Alcohol consumption > 15 units/week and > 3/day;

2. Drug abuse;

3. Former participation in a cognitively challenging computer task or mental performance test;

4. Heavy exercise or sports training > 10 hours/week;

5. Hyperhidrosis , Hypohidrosis or Anhidrosis;

6. Known allergy to cosmetics;

7. Mental status that is incompatible with the proper conduct of the study;

8. Participation in any scientific study with oral, intravenous or inhalatory administration of any substances during two (2) months before study start that could interfere with the MOIST study;

9. Psychiatric disorders;

10. Use of anti-anxiety medications or beta-blockers, statins or blood pressure medication;

11. Use of antibiotics during the six (6) months prior to study start;

12. Use of topical medications in underarm area during 2 weeks prior to study start;

13. Recurring infections, boils, abscesses or lymph node enlargement in the underarm and ;

14. Active eczema or psoriasis on any portion of the body.

15. Personnel of the research institute(s) involved in execution of the study, their partner and their first and second degree relatives;

16. Not having a general practitioner, not allowing disclosure of participation to the general practitioner or not allow to inform the general practitioner about abnormal results.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
adapted STMST
Participants are subjected to the adapted STMST to induce emotional sweating.

Locations

Country Name City State
Netherlands NIZO Ede Gelderland

Sponsors (2)

Lead Sponsor Collaborator
NIZO Food Research Procter and Gamble

Country where clinical trial is conducted

Netherlands, 

Outcome

Type Measure Description Time frame Safety issue
Primary stress-induced malodor formation Expert assessments of stress-induced malodor formation by emotional stress in the armpits of healthy male volunteers Change from baseline malodour formation 20 min, 40 min, and 60 minutes after the start of exposure to the adapted STMST
Secondary Salivary cortisol Emotional stress in healthy male volunteers as assessed by cortisol in saliva Change from baseline salivary cortisol 5 min, 20 min, 30 min, 40 min, 50 min, 60 min, and 70 minutes after the start of exposure to the adapted STMST
Secondary Self-assessed mood state Emotional stress in healthy male volunteers as assessed by self-assessed mood state (VAS) Change from baseline self-assessed mood state 5 min, 20 min, 30 min, 40 min, 50 min, 60 min, 70 min, and 90 minutes after the start of exposure to the adapted STMST
Secondary Malodor compounds formation The malodor compounds formation as assessed by GC-MS/MS analyses during conditions of emotional sweating Change from baseline malodour compounds formation 75 minutes after the start of exposure to the adapted STMST
See also
  Status Clinical Trial Phase
Completed NCT03524105 - Promoting Success for Pre-K Teachers, Families and Children N/A
Terminated NCT01430832 - Developmental Outcomes of Extreme Prematurity, 5-15 Years Postpartum
Completed NCT04091633 - School Health Implementation Network: Eastern Mediterranean N/A
Active, not recruiting NCT05264415 - Intergenerational Transmission of Traumatic Stress N/A
Recruiting NCT05239065 - Personalized Stress Management With Application of Portable Devices in Occupational Populations N/A
Not yet recruiting NCT04551274 - Music Therapy in Frontline Healthcare Workers N/A
Completed NCT04159272 - Effects of Mindfulness Training on the Emotional Experience and (Non-) Acceptance of Emotions in Adolescents N/A
Recruiting NCT03035669 - Effects of Mindfulness Training on Emotion Regulation and Social Cognition. N/A
Active, not recruiting NCT04421235 - Expanding Knowledge About and Evaluating Services for Incarcerated Pregnant and Postpartum Women in Arkansas N/A
Completed NCT04958941 - CUIDA-TE, an APP for the Emotional Management N/A
Active, not recruiting NCT04276363 - Families, Children and Teachers Thriving Together N/A
Completed NCT03908190 - Personalized Support for Progress (PSP) in a VA Women's Wellness Clinic N/A
Completed NCT04430439 - Emotion-Diet Interactions in Pregnancy N/A
Completed NCT03096171 - Flourishing App: An Evaluation With High School Students N/A
Recruiting NCT04963621 - RCT of CESIP for Children With Emotional and Stress Problems N/A
Not yet recruiting NCT04391530 - The Effect of Breath Therapy and Emotional Freedom Technique on Public Speaking Anxiety N/A
Recruiting NCT03969771 - A Mindfulness Based Intervention as a Key Component of Successful Workplace Functioning and Personal Well-being N/A
Completed NCT02755012 - Impact of Maternal Stress on Infant Stunting N/A
Not yet recruiting NCT05385198 - VOICE Study in China 'Towards a Partnership Between Parents of Very Premature Infants and Healthcare Professionals' N/A
Completed NCT05750420 - Psychological Status and Self-care in Chronic Cardiovascular Disease